Fibrinogen degradation product

Fig. 9. Steps in the formation of fibrinogen-fibrin degradation products. The approximate molecular masses of fibrinogen degradation products in kilodaltons (KDa) are indicated.

La Duca F. M. Stimulation of fibrinogen synthesis in cultured rat hepatocytes by fibrinogen degradation product fragment D. Proc Natl Acad Sci USA 1989 86, 8788-92. 

Nham, S. U., and Fuller, G. M. (1986). Effect of fibrinogen degradation products on production of hepatocyte stimulating factor by a macrophage cell line (P388D1). Thromb. Res. 44, 467-475. 

Takaki, A., Yoshitake, S., Ishiguro, M., and Funatsu, M. (1972). Anticoagulant peptide obtained from fibrinogen degradation products by plasmin. II. Sequence determination of the peptide. Proc. Japan Acad., 48, 525-538. 

Fig. 9. The effect of ammonium sulfate (1.2 M) on second antibody separation of the bound fraction in a radioimmunoassay for the fibrinogen degradation product, fragment E (FgE). In the presence of ammonium sulfate, complete precipitation of the bound fraction occurs at considerably reduced concentrations of second antibody despite a much shorter incubation period — , 30 min, 1.2 M (NHiljSOi O—O, 24 hr, no (NH4>jS04. From Martin and Landon. ...

Peorsdike EIB, Gabnakis DK. Platelet adhesion to late fibrinogen degradation products. Blood Coag Fibrinolys 1996 7 353-360. 

Blood fibrinogen degradation products - increased Blood fibrinogen - variable Blood platelets - decreased Blood prothrombin time - increased... 

Forster, C., Whalley, E. T., 1981 Possible functional role of fibrinogen degradation products in cerebral arterial spasm. J. Cereb. Blood Flow Metab. (Suppl. 1) 1, S564. 

It is supposed that the renal disturbance was due to intravascular coagulation developing on the basis of hypovolaemia (caused by diarrhoea and vomiting), and the presence of fibrin and fibrinogen degradation products. 

---