Fiber-optic-based biocatalytic biosensors

Arnold M.A. (1989) Fiber-optic based biocatalytic biosensors. A.C.S. Symposium Series, 403, 303-317. 

In addition to the development of absorbance-based fiber-optic biosensors, we have recently demonstrated the feasibility of fluorescence-based biosensors (9, 10). Our initial work in this area has focused on the development of fiber-optic biosensors based on the fluorometric detection of reduced nicotinamide adenine dinucleotide (NADH). Here, a dehydrogenase enzyme supplies the biocatalytic activity, and either the generation or consumption of NADH is oionitored. 

Aizawa presented an overview on the principles and applications of the electrochemical and optical biosensors [61]. The current development in the biocatalytic and bioaffinity bensensor and the applications of these sensors were given. The optical enzyme sensor for acetylcholine was based on use of an optical pH fiber with thin polyaniline film. 

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