Fever immunoglobulin

Adverse reactions occurring in 3% or more of patients with RA include the following Nausea, dyspepsia, rash, headache, abdominal pain, vomiting, fever, dizziness, stomatitis, pruritus, abnormal liver function tests, and leukopenia. One report showed a 10% rate of immunoglobulin suppression, which was slowly reversible and rarely accompanied by clinical findings. 

Idiosyncratic dmg reactions (IDRs) are most commonly characterized by a reaction involving fever or rash, with or without internal organ involvement. The spectrum of responses ranges from a minor rash, to potentially fatal toxic epidermal necrosis and Stevens-Johnson syndrome. Immunoglobulin E (IgE)-mediated anaphylactic shock, occasional joint pain, hepatotoxicity or nephrotoxicity are also well documented [24]. The frequency of such reactions are unknown but estimated to be between 1 1000 and 1 10000 exposures and may be enhanced on re-challenging susceptible individuals with the same dmg. 

Adverse effects include local tenderness, muscle soreness or stiffness at the injection site, low grade fever, sensitisation to repeated injections of human globulin in immunoglobulin deficient patients. 

Hay fever, or allergic rhinitis, is an allergic reaction induced by an immunoglobulin-mediated inflammatory response of the nasal mucosa to allergens, particularly pollen. 

Of 56 patients with autoimmune diseases who received high dosages of intravenous immunoglobulin, 20 had at least one adverse effect after one or more courses of treatment (12). The most frequently reported adverse effects were low-grade fever, headache, and chills. The authors concluded that the occurrence of adverse effects with intravenous immunoglobulin was not related to the clinical response to treatment. However, patients who developed adverse effects during the first course of treatment were more at risk of adverse effects during subsequent courses. 

The most frequent adverse effects of intravenous immunoglobulin (Sandoz) for the treatment of various disorders (affecting 1-3% of patients in aU) were headache, nausea, vomiting, and fever. Some other mild sjmp-toms have an incidence below 1%, including abdominal pain, diarrhea, fatigue, malaise, dizziness, myalgia, and chest tightness. 

Intravenous immunoglobulin can cause malaise and fever in patients with infections, probably through a temporarily increased titer of antibodies against different pathogenic microorganisms (124). 

Yellow fever vaccine may be administered simultaneously with all other vaccines except cholera a 3-week interval between vaccines is recommended. Simultaneous administration of immunoglobulin does not interfere with the immune response to this agent. 

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