Muscle rigidity fentanyl

Skeletal muscle r/g /cf/fy Alfentanil, fentanyl, and sufentanil may cause skeletal muscle rigidity, particularly of the truncal muscles. The incidence and severity of muscle rigidity is usually dose-related. Alfentanil, fentanyl, and sufentanil may produce muscular rigidity that involves all skeletal muscles, including those of the neck and extremities. 

Opioid-induced muscle rigidity is a frequent complication of this form of anesthesia. It is most common with phenylpiperidine drugs and occurs even after low doses of fentanyl, such as those used in certain diagnostic or minor surgical procedures where a pain-free... 

There have been three reports and a prospective study of muscle rigidity after fentanyl administration in neonates (18,19). 

Muller P, Vogtmann C. Three cases with different presentation of fentanyl-induced muscle rigidity—a rare problem in intensive care of neonates. Am J Perinatol 2000 17(l) 23-6. 

The use of fentanyl may cause severe chest compressions, due to the induction of skeletal muscle rigidity. 

C) Chest muscle rigidity often follows the administration of fentanyl... 

Remifentanil has been studied in neonates undergoing elective endotracheal intubation [178 ]. They were randomized to remifentanil 3 micrograms/kg-I-isotonic sahne ( = 15) or fentanyl 2 micrograms/kg - - suxamethonium 2 mg/kg. There was chest wall rigidity in two of the infants who received remifentanil. Muscle rigidity remains a concern in doses of 3 micrograms/kg in this age group. 

Musculoskeletal Muscle rigidity resulting in reduced thoracic waU compliance occurred intraoperatively in a 2-year-old child soon after fentanyl administration, although the dose was low (1 microgram/kg) [69 ]. 

Side-effects The side-effect profile (Poklis, 1995) is typical of potent p-opioids with respiratory depression, increased muscle tone (chest wall rigidity during fentanyl anesthesia), strong sedation and emesis being most prominent. Adverse reactions can be antagonized with naloxone. 

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