Fenofibrate pharmacokinetics

Jones MR, Baker BA, Mathew P. Effect of colesevelam HCl on single-dose fenofibrate pharmacokinetics. Clin Pharmacokinet (2004) 43,943-50. 

However, in a formal study bezafibrate and fenofibrate did not affect the pharmacokinetics or pharmacodynamics of a single dose of repaglinide 0.25 mg (63). 

Kajosaari LI, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ. Lack of effect of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide. Br J Clin Pharmacol 2004 58 390-6. 

Kosoglou T, Statkevich P, Fruchart JC, Pember LJ, Reyderman L, Cutler DL, Guillaume M, Maxwell SE, Veltri EP. Pharmacodynamic and pharmacokinetic interaction between fenofibrate and ezetimibe. Curr Med Res Opin 2004 20(8) 1197-207. 

Mathew, P., Cuddy, T. and Tracewell, W.G. (2004) An open-label study on the pharmacokinetics (PK) of pitavastatin (NK-104) when administered concomitantly with fenofibrate or gemfibrozil in healthy volunteers (abstract PI-115). Clinical Pharmacology and Therapeutics, 75, 33. 

In a study in healthy subjects, fenofibrate 200 mg once daily for 5 days had no effect on the pharmacokinetics of a single 250-microgram dose of repaglinide, and did not alter the glucose-lowering effect of repaglinide. ... 

The use of bezafibrate with ciclosporin has resulted in significantly increased serum creatinine and reductions, no change, or increased serum ciclosporin levels. The use of fenofibrate has also been associated with reduced renal function and possibly reduced serum ciclosporin levels. Two studies found no pharmacokinetic interaction between ciclosporin and gemfibrozil while a third found gemfibrozil caused a significant reduction in ciclosporin levels. 

Colestyramine does not alter the pharmacokinetics of clofibrate when both drugs are given at the same time. Similarly colestipol does not alter the pharmacokinetics of clofibrate or fenofibrate, and colesevelam does not alter the pharmacokinetics of fenofibrate. Colestipol can reduce the absorption of gemfibrozil if given at the same time, but not if administration is separated by 2 hours. A similar interaction occurs between bezafibrate and colestyramine... 

Harvengt C, Desager JP. Lack of pharmacokinetic interaction of colestipol and fenofibrate in volunteers. Eur J Clin Pharmacol ( 9S0) 17, 459-63. 

Gustavson LE, Schweitzer SM, Koehne-Voss S, Achari R, Chira TO, EssUnger H-U, Yanni-celli HD. The effects of multiple doses of fenofibrate on the pharmacokinetics of pravastatin and its 3a-hydro) isomeric metabolite. J Clin Pharmacol (2005) 45, 947-53. 

Martin PD, Dane AL, Schneck DW, Warwick MJ. An open-label, randomized, diree-way crossover ttial of the effect of coadministration of rosuvastatin and fenofibrate on die pharmacokinetic properties of rosuvastatin and fenofibric acid in healthy male volunteers. Clin Ther(2003) 25, 459-71. 

Bergman AJ, Murphy G, Burke J, Zhao JJ, Valesky Liu L, Lasseter KC, He W, Prueksar-itanont T, QiuY, Hartford A, Vega JM, Paolini JF. Simvastatin does not have a clinically significant pharmacokinetic interaction widi fenofibrate in humans. J Clin Pharmacol (2004) 44, 1054-62. 

Pan WJ, Gustavson LE, Achari R, et al. Lack of a clinically significant pharmacokinetic interaction between fenofibrate and pravastatin in healthy volunteers. J Clin Pharmacol 2000 40 316-323. 

Vaidyanathan S, Maboudian M, Warren V, Yeh CM, Dieterich HA, Howard D, Dole WP. A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with metformin, pioglitazone and fenofibrate in healthy subjects. Curr Med Res Opin 2008 24(8) 2313-26. 

Fenofibric acid+a statin Fenqftbric acid (Trilipix ), the choline salt of fenofibrate, is designed to overcome the drawbacks of older fibrates, particularly in terms of pharmacokinetic properties. It is well absorbed and is not subject to first-pass hepatic metabolism. The combination of fenofibric acid with statins is used to improve the lipid profile compared with the corresponding statin dose. The use of combination of fenofibric acid with statins has been reviewed [12]. 

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