Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Fendiline hydrochloride

Chemical Name 7-phenyl-N-( TphenylethyDbenzenepropanamine hydrochloride Common Name N-(1-phenylethyl)-3,3-diphenyl-propylamine [Pg.623]

13 grams of 7,7-diphenyl-propylamine and 12.01 grams of acetophenone are hydrogenated in 200 ml of methanol at SS C and a pressure of 10 atmospheres in the presence of palladium charcoal. On filtration of the catalyst the solution is concentrated and the remainder is distilled in vacuo at a pressure of 0.3 Hg mm. The main distillate is collected at 206° to 210°C. 25.38 grams of N-[ 1 -phenylethyl-( 1 )]-1,1-diphenyl-propyl-(3)-amine are obtained. [Pg.623]

The product is dissolved in 134 ml of 96% ethanol whereupon 26.8 ml of concentrated hydrochloric acid and 201 ml of water are added while cooling with ice-water. The pre- [Pg.623]

Harsa nyi, K., Korbonits, D Taka ts, K.,Tardos, L.and Leszkovszky,G. U.S, Patent 3,262,977 July 26, 1966 assigned to Chinoin Gyo gyszer-e s Vegyeszeti Terme kek, Hungary [Pg.624]

Chemical Name 7-phenyl-N-(1-phenylethyl)benzenepropanamine hydrochloride [Pg.623]

ABSTRACT Fendiline hydrochloride [N-/1-phenylethyl/-3 9 3-diphenylpropylamine.HC is a sparingly soluble and hardly absorbable coronary vasodilator The fendiline base forms complex ivith /3-cyclodextrin in a molar ratio of 1 2 The enhanced solubility and dissolution rate of the complex resulted in a better bioavailability of the drug,... [Pg.503]

Fendiline-hydrochloride (trade name Sensit, chemical name N-/l-phenylethyl/-3,3-diphenylpropylamine HC is a coronary vasodilator, a sparingly soluble drug /l/ ... [Pg.503]

Dissolution rate and solubility of the fendiline-base- /3-cyclodextrin /F- (iCD/ complex at the pH of the gastric juice is much higher than those of the presently marketed fendiline hydrochloride /F HCl/ The X-labelled F HC1 and F- (iCD jeTe orally administered to rats in a dose 5 in /kg and the activity of the blood, serum, urine and faeces was detected for 48 h ... [Pg.505]

Fig.l, Ratios of excreted fendiline administered orally to rats from fendiline-base-/3-cyclodextrin complex /F- 3 CD/ and from fendiline hydrochloride... [Pg.506]

See other pages where Fendiline hydrochloride is mentioned: [Pg.623]    [Pg.623]    [Pg.1568]    [Pg.1568]    [Pg.623]    [Pg.623]    [Pg.623]    [Pg.623]    [Pg.504]    [Pg.623]    [Pg.623]    [Pg.1568]    [Pg.1568]    [Pg.623]    [Pg.623]    [Pg.623]    [Pg.623]    [Pg.504]    [Pg.2280]    [Pg.2280]   


SEARCH



Fendilin

Fendiline

© 2024 chempedia.info