Fenbufen

Therapeutic Function Antiinflammatory Chemical Name 3-(4-Biphenylylcarbonyl)propionic acid Common Name -Structural Formula  

135 g of aluminum chloride is dissolved in 500 ml of nitrobenzene, the solution being held 

Chemical Abstracts Registry No. 36330-85-5 Trade Name Manufacturer 

Ci nopal Lederfen Lederfen Cinopal Napanol Cinopal 8ufemid 

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C12H10 92-52-4) see Bifonazole Fenbufen 4-biphenylacetonitrile (C14H11N J760i-77-7) see Felbinac [3aR-(3aa,4a,5p,6aa)]-[l,l -biphenyl]-4-carboxylic acid 4-formylhexahydro-2-oxo-2fl-cyclopenta[6]furan-5-yl ester (C2iH,80j 38754-71-1) see Latanoprost [3alt-[3aa,4a(l ,35 ),5p,6aa]]-[4,4 -biphenyl]-4-carb-oxylic acid hexahydro-4-(3-hydroxy-5-phenyl-l-pentenyl)-2-oxo-21/-cyclopenta[6]furan-5-yl ester (C3 H ,05 41639-73-0) see Latanoprost... 

Oumada et al. [148] described a new chromatographic method for determining the aqueous pKa of dmg compounds that are sparingly soluble in water. The method uses a rigorous intersolvent pH scale in a mobile phase consisting of a mixture of aqueous buffer and methanol. A glass electrode, previously standardized with common aqueous buffers, was used to measure pH online. The apparent ionization constants were corrected to a zero-cosolvent pH scale. Six sparingly soluble nonsteroidal antiinflammatory weak acids (diclofenac, flurbiprofen, naproxen, ibu-profen, butibufen, fenbufen) were used successfully to illustrate the new technique. 

While some arylaliphatic acids are established as antiinflammatory agents, it is interesting to note that some arylketones share this activity. Fenbufen... 

False substrates, 161 Famotine, 37 Fantridone, 421 Fenalamide, 81 Fenbufen, 126 Fenclorac, 66 Fenclozic acid, 269 Fenestrel, 9 Fenimide, 237... 

Apart from the salicylates NSAIDs include several classes of weak acids like propionic acid derivatives such as ibuprofen, carprofen, fenbufen, fenoprofen, flurbiprofen, ketorolac, loxoprofen, naproxen, oxaprozin, tiaprofenic acid and suprofen. Phenylbutazone is the most important representative of the pyrazolon derivatives which have a bad reputation for their risk of potentially fatal bone-marrow toxicity. To the acetic acid derivatives belong in-domethacin, diclofenac and sulindac. Sulindac is a pro-drug with less toxicity than indomethacin. The enolic acids include piroxicam, droxicam and tenoxicam. Meloxicam is an analog of piroxicam and has a high selectivity for COX-2. 

Fig. 3. Examples of input and output of SAMURAl-GUl system. An example of analysis with queries tnts (a) the CellMontage format as input and (b) graphical output of modules that share common biological function. Four example modules are searched by Benzbromarone, Fenbufen, Clofibrate, and Dichloroacetate. KEGG pathway functions for each module with the first and the second most significant p values are only shown.

Synthesis Fenbufen is prepared by the Friedel-Crafts (aluminum chloride-nitrobenzene) acylation of biphenyl with succinic anhydride (Tomcufcik et al. (American Cyanamid Co.), 1972). 

Brogden, R. N., Heel, R. C., Speight, T. M., Avery, G. S. Fenbufen a review of its pharmacological properties and therapeutic use in rheumatic diseases and acute pain. Drugs 1981a 21, 1-22. 

Figure 7.9 Typical SFC separation of flufenamic acid (1), mefenamic acid (2), acetylsalicylic acid (3), ketoprofen (4), and fenbufen (5) on a SB-cyanopropyl-50 column. [Reprinted from Ref. 6, J. Chromatogr. 604, 255 (1992) with kind permission of Elsevier Science Publishers, The Netherlands.]...

HPLC Grind,ultrasonicate with H20/CH5CN, filter Silica 5 mAf P04, pH 2.6-CH3CN (95 5), 1 ml/min 254 nm Resolved aspirin, fenbufen, ibuprofen, indomethacin, ketoprofen, sulindac, naproxen, tolmetin [178]... 

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