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Fenclozic acid

Fenclofenac 37 Fenclorac 66 Fenclozic acid 269 Fendosal Fenestrel 9 Fenethylline U 425 Fenfluramine 1, 70 Fenimide 2T7 Fenisorex 391... [Pg.268]

The thiazole ring has been found to be an occasional surrogate for a phenyl ring in certain antiinflammatory agents. Note that the side chain is restricted to a simple acetic acid in this series. Reaction of p-chloro-2-mercaptoacetophenone (198) with ethyl cyanoacetate in the presence of base affords thiazole 200. The reaction may involve an adduct such as the iminothioether 199 as an intermediate. Saponification of the ester moiety of 200 then gives the antiinflammatory agent fenclozic acid... [Pg.269]

The first major new drug to be approved and withdrawn from the market by the CSD was ibufenac, the first of the non-steroidal antiinflammatory drugs (NSAID) to be marketed. Ibufenac was a precursor of ibuprofen and its use in the United Kingdom was associated with serious and frequent hepatotoxicity. Two other drug withdrawals (also approved during their tenure by CSD) were chlormadinone and fenclozic acid. [Pg.469]

False substrates, 161 Famotine, 37 Fantridone, 421 Fenalamide, 81 Fenbufen, 126 Fenclorac, 66 Fenclozic acid, 269 Fenestrel, 9 Fenimide, 237... [Pg.1011]

Common Name Acidum fenclozicum Fenclozic acid Fenclozin Structural Formula ... [Pg.1567]

New and Experimental Agents - Arvlalkanoic Acids - Considerably more clinical data is now available for fenclozic acid (l) (Myalex ,... [Pg.227]

See other pages where Fenclozic acid is mentioned: [Pg.497]    [Pg.1003]    [Pg.675]    [Pg.1566]    [Pg.1566]    [Pg.1567]    [Pg.1567]    [Pg.623]    [Pg.262]   
See also in sourсe #XX -- [ Pg.269 ]

See also in sourсe #XX -- [ Pg.2 , Pg.269 ]

See also in sourсe #XX -- [ Pg.184 ]

See also in sourсe #XX -- [ Pg.227 ]

See also in sourсe #XX -- [ Pg.262 ]



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