Fatty acids nitration mechanisms

Mechanisms of Fatty Acid Nitration Chanical and Cell Synthesis... 

It should be noted that Reaction (4) is not a one-stage process.) Both free radical N02 and highly reactive peroxynitrite are the initiators of lipid peroxidation although the elementary stages of initiation by these compounds are not fully understood. (Crow et al. [45] suggested that trans-ONOO is protonated into trans peroxynitrous acid, which is isomerized into the unstable cis form. The latter is easily decomposed to form hydroxyl radical.) Another possible mechanism of prooxidant activity of nitric oxide is the modification of unsaturated fatty acids and lipids through the formation of active nitrated lipid derivatives. 

Trostchansky, A. Rubbo, H., Nitrated fatty acids Mechanisms of formation, chemical characterization, and biological properties. Free a cBiolM 2008,44(11), 1887—96. 

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