Familial breast cancer, pancreas

BRCA-2 DNA repair familial breast cancer, pancreas... 

The effect of various peptides and growth factors in small cell lung cancer cells has been reported by Bepler et al [121]. Four peptides isolated from completely different sources with structural similarities represent members of a new family of growth factors [121]. These peptides include 1) a 60 amino acid residue breast cancer- associated pS2 peptide isolated from human gastric juice and the culture media of the human breast cancer cell line MCF-7, 2) a 106 amino acid residue pancreatic spasmolytic polypeptide (PSP) isolated from porcine pancreas and 3) a 49 and 50 amino acid residue peptide predicted from a cyclic DNA isolated from the skin of frog, Xenopus laevis. 

Borg A, Sandberg T, Nilsson K, et al. High frequency of multiple melanomas and breast and pancreas carcinomas in CDK-N2A mutation-positive melanoma families. J Natl Cancer Inst. 2000 92 1260-1266. 

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