Falcipain

CA C1 C01.046 Falcipain-2 Potential drug target for malaria infection... 

S-Adenosylmethionine carboxylase Sex-hormone binding globulin CYP 2D6 Falcipain 2 and 3 SARS CoV Chkl kinase Heme oxygenase... 

Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum. Molecular Microbiology 45, 1245-1254. 

Shenai BR, Sijwali PS, Singh A et al (2000) Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. J Biol Chem 275 29000-29010... 

Fig. 6 Structures of epoxide-based inhibitors and activity-based probes used in the study of falcipain 1...

Greenbaum DC, Baruch A, Grainger M, Bozdech Z, Medzihradszky KF, Engel J, DeRisi J, Holder AA, Bogyo M (2002) A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science 298 2002... 

Figure 1 Ordered pathway of hemoglobin catabolism. Host Hb cleavage is initiated by PfPMI and PfPM2. Hb unfolds, releases heme and exposes other peptide bonds to the falcipains. Resultant protein fragments are degraded even more by falcilysin and transported to the cytosol where they are broken down into needed amino acids. The heme released in the first step aggregates via biomineralization to form HZ.

Eksi, S., Czesny, B., Greenbaum, D. C., Bogyo, M., and Williamson, K. C. (2004). Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth. Mol. Microbiol. 53, 243-250. 

Sijwali, P. S., and Rosenthal, P. J. (2004). Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proc. 

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