Fahlberg, Constantin

Saccharin is, of course, the famous artificial sweetener. It was discovered at Johns Hopkins University in 1879 in the days before disposable gloves. Ira Remsen (1846-1927) asked a research fellow Constantin Fahlberg (1850-1910) to oxidize a sulfonamide he had made. Fahlberg did so and found that evening that the food he was eating tasted remarksbly sweet. Saccharin is a cyclic imide with a nitrogen atom acylated on one side by a sulfonic add and on the other by a carboxylic acid. 

Saccharine s has been for a long time a widely used and very successful sweetener. It was discovered in 1879 by chance, by Constantin Fahlberg, a graduate student at Johns Hopkins University in the USA. Fahlberg was a student of Professor Ira Remsen who had instructed him to synthesize derivatives of the substance toluene. He made one derivative, and then noticed at lunch that his bread tasted sweet. He realized that he had not washed his hands since working in the laboratory and the sweet taste was due to the chemical he had made. He called it saccharine, left the university department, applied for a patent and, despite opposition and annoyance from the university and Professor Remsen, eventually succeeded in his apphcation for a patent in 1885. 

Saccharin was the first artificial sweetener, discovered in 1879 by Constantin Fahlberg at Johns Hopkins University. The Monsanto Chemical Works was incorporated in 1901 to produce saccharin in the United States. Saccharin is easy to make, stable when heated, and is approximately 300 times sweeter than sncrose when equal quantities are compared. One common saccharin product is Sweet and Low. 

Saccharin, the first synthetic sweetener, was discovered by Ira Remsen and his student Constantine Fahlberg at Johns Hopkins University in 1878. Fahlberg was studying the oxidation of ortho-substituted toluenes in Remsen s laboratory when he found that one of his newly synthesized compounds had an extremely sweet taste. (As strange as it may seem today, at one time it was common for chemists to taste compounds in order to characterize them.) He called this compound saccharin, and it was eventually found to be about 300 times sweeter than glucose. Notice that, in spite of its name, saccharin is not a saccharide. 

Saccharin, the first artificial sweetener discovered, is synthesized accidentally by Johns Hopkins researchers Constantine Fahlberg and Ira Remsen. 

In contrast, the first artificial sweetener, saccharin, is a substance that also contains sulfur (Figure 48.1). The American chemist Ira Remsen (1846-1927), together with his German student Constantin Fahlberg, investigated the substance benzosul-famide in 1880. They observed its remarkable sweetness and called it saccharin. For a compound to taste sweet, it must be able to cause a nerve impulse to carry the mes-... 

Saccharin is commonly known as a widely used noncaloric synthetic sweetener. It is the oldest nonnutritive synthetic sweetener, having been on the market for more than 100 years. Saccharin was accidently discovered by Ira Remsen and Constantin Fahlberg, researchers at John Hopkins University in 1879. Saccharin is commercially... 

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