Factors and Molecular Mechanisms that Modulate Neurodegeneration in Neurodegenerative Diseases

2 Factors and Molecular Mechanisms that Modulate Neurodegeneration in Neurodegenerative Diseases 

Another important finding is that many neurodegenerative diseases are characterized by aberrant protein phosphorylation and ubiquitination (Thomas et al., 2009). Thus, disruption of the phosphorylation of neurotransmitter receptors and hyperphosphorylation of t-protein has been implicated in impaired memory function in AD. Similarly, AD also involves aberrant accumulation of proteins that are normally degraded by the ubiquitin-proteasome system. It is suggested that phosphorylation and ubiquitination of proteins can serve biomarkers for neurodegenerative diseases (Thomas et al., 2009). 

---