FAB classification

For all newly diagnosed patients with leukemia, an aspirate of the liquid marrow and a bone marrow core biopsy are obtained.5 Morphologic and cytochemical analysis of these samples distinguishes three subtypes of ALL (LI, L2, and L3) and eight subtypes of AML (M0-M7) as classified by the French-American-British (FAB) scheme. See Tables 92-2 and 92-3 for the FAB classification of acute myelogenous leukemia and acute lymphocytic leukemia. 

TABLE 92-2. Morphologic (FAB) Classification of Acute Myelogenous Leukemia... 

Acute myeloid leukemia (AM L) is a neoplastic proliferation of myeloid hematopoietic stem cells or myeloid precursors including myeloblasts, monoblasts, erythroblasts and megakaryoblasts. According to the FAB classification, AML is classified into eight subtypes (M0-M7) depending on the cell type involved in the neoplastic process. 

Treatment results in childhood acute leukemia continue to be improved due to new therapeutic and diagnostic methods. An optical microscopy method with specific staining allows to classify acute leukemia into lymphoblastic and myeloid types and discriminate its subtypes according to principals of FAB-classification. A flow cytometry method with monoclonal antibodies staining allows us to discriminate different immunophenotypic subtypes of acute... 

Markers on the cell surface or membrane of the lymphoblast can be used to classify ALL. Among the early classification system was the FAB scheme, which was based purely on morphology and cytochemistry. This system considered nuclear appearance and degree of differentiation. This is no longer used, and the current classification of acute leukemias is based on features that can be identified only by immunologic and molecular analyses.3... 

Bacher U, Kern W, Schnittger S, Hiddemann W, Schoch C, Haferlach T. Further correlations of morphology according to FAB and WHO classification to cytogenetics in de novo acute myeloid leukemia A study on 2,235 patients. Ann Hematol 2005 84(12) 785—791. 

The role of chemical exposure and development of ANLL has been quite controversial. This controversy is partially due to the problems associated with accurately and appropriately classifying the various leukemias. Since the mid-1980s, the nomenclature of the ANLL subtypes was established by the French-American-British Cooperative group also known as FAB. Older studies in the literature that do not use this classification scheme present a serious problem since there was a tendency to lump different... 

Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of chronic (mature) B and T lymphoid letrkaemias. French-American-British (FAB) Cooperative Group. J Clin Pathol. 1989 42(6) 567-584. 

Strong, A.B., Jensen, D.W., 2002. The Ultimate Composite Structure. Compos. Fab. 22-27. Taylor, L.W., 2007. Design and manufacture of 3D nodal structures for advanced textile composites. Ph.D. thesis. School of Materials, The University of Manchester, UK. Taylor, L.W., Chen, X., 2015. Three-dimensional nodal woven structure part 1 classification, design and production parameters (to be published). 

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