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Expression Patterns and Response to Known Drugs

The expression patterns of the different ERR subtypes are significantly different [35], ERRa and ERRy are found in adult brain, muscle, kidney, testis and uterus as well as in developing bone, muscle and neuronal tissue. The expression of ERRP is much more narrow with little to no expression in most adult tissues while showing limited expression during development. [Pg.53]

The most profound difference between the ER and ERR families is their ligandbinding profile [35]. No endogenous ligand has been identified for any of the ERRs, leaving them as orphan receptors for now. Members of the ERR family do not bind to estradiol and many of their activities appear to be ligand independent, but they can bind to synthetic ligands. All three ERR family members bind to DES at much higher [Pg.53]

See other pages where Expression Patterns and Response to Known Drugs is mentioned: [Pg.49]    [Pg.52]    [Pg.53]    [Pg.55]    [Pg.49]    [Pg.52]    [Pg.53]    [Pg.55]    [Pg.159]    [Pg.15]    [Pg.345]    [Pg.403]    [Pg.1420]    [Pg.517]    [Pg.672]    [Pg.19]    [Pg.612]    [Pg.613]    [Pg.480]    [Pg.523]    [Pg.318]    [Pg.267]    [Pg.214]    [Pg.178]    [Pg.400]    [Pg.74]   


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Drug patterns

Known

Known response

Knowns

Response patterns and

Response to drug

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