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Exploring Multivalent Interactions

Bioactive Materials from ROMP Exploring Multivalent Interactions... [Pg.218]

The second chapter is a comprehensive summary of the polyvalent molecular architectures which have been conceived and synthesized in order to interfere in microbial adhesion processes on cell surfaces, an event where multivalent interactions most often are a prerequisite. Molecular constructs as described in this section can serve to investigate and manipulate fimbriae-mediated bacterial adhesion, as in the case of E. coli type 1 fimbriae-mediated bacterial adhesion, which is explored in all structure-biological details in the third chapter. In the following contributions in Chapters 4 and 5, more implications and reflections about bacterial adhesins and... [Pg.195]

To explore interactions of multivalent ligands with ConA, polymers with pendant maimose or glucose residues have been generated by ROMP. The saccharide epitopes were attached to norbornene monomers through C-glycoside linker units... [Pg.237]

L.L. Kiessling, J.E. Gestwicki, L.E. Strong, Synthetic multivalent ligands in the exploration of cell-surface interactions, Curr. Opin. Chem. Biol. 2000, 4, 696-703. [Pg.662]

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