Experimental Support of Model Assumptions

TABLE 3.6 Predicted Potency Distributions Using the Ideal Mixing Model for Progressively Smaller Mean Drug Particle Diameters and a Geometric Standard Deviation of 2 

Potency Range (%) Number of Units Out of 100,000 in the Given Potency Range for the Indicated Mean Particle Size in Micrometers  

Potency Range (%) 1.3 xg Dose 29 xm Mean Particle Size 3.6 xg Dose 22 j.m Mean Particle Size 

The particle size analysis of Rohrs et al. also showed that a geometric standard deviation of 2 gives a reasonable characterization of the distribution in the larger particle size region. 

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