Expanding the Genetic Code

Wang L, Xie J, Schultz PG (2006) Expanding the genetic code. Annu Rev Biophys Biomol... 

Wang, L. and Schultz, P. G. (2002) Expanding the genetic code. Chem. Commun. 1-11. 

Expanding the Genetic Code Through Chemical Biology Protein Syndiesis, Key Reactions of Protein-Nucleic Acid Interactions Translation An Overview... 

Proteins Structure, Function, and Stability Expanding the Genetic Code Through Chemical Biology Synthetic Proteins, Design and Engineering of Phage Display... 

Expanding the Genetic Code Through Chemical Biology Metallo-enzymes and Metallo-Proteins, Chemistry of Proteins, in vivo Chemical Modification of... 

Wang L, Schultz PG. Expanding the genetic code. Angew. Chem. Int. Ed. Engl. 2004 44 34-66. 

RNAs that employ the four standard bases have more limited opportunities for hydrogen-bonding interactions and functionality, even though the range of tertiary interactions is broad (63). The use of additional base pairs would not only increase the stmctural complexity of RNA but would also allow for enzymatic replication. This concept has been exploited by several research groups to expand the genetic code, as well as to generate novel, site-specihcally modihed RNAs (e.g., biotinylated, huorescent, cross-linked RNAs) (6, 29, 64). 

Expanding the genetic code using unnatural amino acids with heterocyclic fragments 02CC1. 

Application of the metal-ligand incorporation in nucleic acid duplexes either to expand the genetic code or to create extended, metal-containing nanostmc-tures requires that several metal complexes are incorporated into one nucleic acid duplex. This is a difficult task because the presence of multiple ligands situated in close proximity of each other within the same oligomer makes possible the formation of different stmctures for the nucleic acid, (e.g., hairpin... 

L. Wang, A. Brock, B. Herberich, P.G. Schultz, Expanding the genetic code of Escherichia coli, Science 2001, 292, 498-500. 

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