Exogenous agent exposure

Although commonly formed from endogenous material, the occurrence of synovial crystals formed following environmental exposure to exogenous agents is indicated by the identification of both aluminium phosphate and aluminium silicate particulates (Netter etal., 1983, 1991). It is noteworthy in this context that arthritic symptoms have been reported following the... 

It has been foxmd that a combined application of cosmetic and facial rubbing can cause exogenous inflammatory acne. Exogenous acne refers to acneiform lesions due to external factors such as cosmetic agents, exposure to various oils, skin mbbing or friction or chlorance, now better called metabolizing acquired dioxin-induced skin hamartoma. 

Figure 5.2 Therapeutic interventions for decreasing colorectal mucosal bile acid exposure as a CRC chemoprevention strategy. 1) Lifestyle modifications including reduction in dietary animal fat and increased fibre intake may, at least partly, be explained by reduction in luminal primary (cholic acid [CA] and chenodeoxycholic acid [CDCA]) and secondary (deoxycholic acid [DCA] and lithocholic acid [LCA]) bile acids. 2) Reduction of secondary bile acids, which are believed to have pro-carcinogenic activity could be obtained by decreased bacterial conversion from primary bile acids. 3) Alternatively, bile acids could be sequestered by chemical binding agents, e.g. aluminium hydroxide (Al(OH)3) or probiotic bacteria. 4) Exogenous ursodeoxycholic acid (UDCA) can reduce the luminal proportion of secondary bile acids and also has direct anti-neoplastic activity on colonocytes in vitro.

Chromosomal DNA is often damaged by exposure to exogenous (i.e., UV irradiation, chemical agents, etc.) and endogenous (i.e.. 

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