Examples of Condensed-phase Reactions

In the equilibrium-secondary-zone approximation [82, 85] we refine the effective potential along each reaction path by adding the charge in secondary-zone free energy. Thus, in this treatment, we include additional aspects of the secondary subsystem. This need not be more accurate because in many reactions the solvation is not able to adjust on the time scale of primary subsystem barrier crossing [86]. 

Although a more recent calculation [88] indicates a barrier height about 2 kcal moH higher than that on the potential energy surface used for these studies, the qualitative conclusions still hold if they are regarded as based on a realistic model reaction. 

---