Examples for a Single Batch Chromatographic Column

To demonstrate the equality of concentration profiles, results from simulation of a transport-dispersive model with different design and operating parameters but identical number of stages and loading factor are compared. Here, it has to be kept in mind that these model calculations agree with experiments within measurement accuracy (Chapter 6). 

The first exemplary problem is the separation of a racemic mixture EMD53986 R S-enantiomers = 1 1) on the chiral stationary phase Chiralpak AD from Daicel (20 pm particle diameter) (Table 7.1). 

Since the concentration profiles for this exemplary system are not perfectly identical, scale-up has to be done with caution. Especially, the greater than or equal to condition (Equation 7.42 or 7.44) has to be fulfilled for all components. Therefore, in this case it is not sufficient to look only at the number of stages of one component, but the number of stages of all components has to be taken into account. 

In summary the transport-dispersive model together with the simplified degrees of freedom N and LF is very useful for optimization and scale-up of chromatographic processes. 

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