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Evolution enzyme model systems

Quantum mechanics is essential for studying enzymatic processes [1-3]. Depending on the specific problem of interest, there are different requirements on the level of theory used and the scale of treatment involved. This ranges from the simplest cluster representation of the active site, modeled by the most accurate quantum chemical methods, to a hybrid description of the biomacromolecular catalyst by quantum mechanics and molecular mechanics (QM/MM) [1], to the full treatment of the entire enzyme-solvent system by a fully quantum-mechanical force field [4-8], In addition, the time-evolution of the macromolecular system can be modeled purely by classical mechanics in molecular dynamicssimulations, whereas the explicit incorporation... [Pg.79]

CONTENTS Preface, C. Allen Bush. Thermodynamic Solvent Isotope Effects and Molecular Hydrophobicity, Terrence G. Oas and Eric J. Toone. Membrane Interactions of Hemolytic and Antibacterial Peptides, Karl Lohner and Richard M. Epand. Spin-Labeled Metabolite Analogs as Probes of Enzyme Structure, Chakravarthy Narasimhan and Henry M. Miziorko. Current Perspectives on the Mechanism of Catalysis by the Enzyme Enolase, John M. Brewer and Lukasz Leb-ioda. Protein-DNA Interactions The Papillomavirus E2 Proteins as a Model System, Rashmi S. Hedge. NMR-Based Structure Determination for Unlabeled RNA and DNA, Philip N. Borer, Lucia Pappalardo, Deborah J. Kenwood, and Istvan Pelczer. Evolution of Mononuclear to Binuclear CuA An EPR Study, William E. Antholine. Index. [Pg.308]

The limiting stoichiometry of the Mo-based enzyme Equation (11) is identical to that of Equation (12), implicating the obligatory evolution of one molecule of dihydrogen arising from generation of a vacant site on the enzyme at which dinitrogen can bind [61]. This has been elaborated upon in (i) the mechanism of action of the enzyme and (ii) model systems. [Pg.480]

This conjecture is corroborated by the fact that the enzymic model possesses other properties shared by neurons of the thalamus. Reminiscent of the phenomenon described in section 3.3, two distinct thresholds of excitability, linked to two voltage-dependent Ca conductances, have been demonstrated in these neurons by Jahnsen Llinas (1984a). Moreover, the evolution towards a stable steady state takes a different form, depending on the initial state of the system. Thus, in... [Pg.110]

It also seems clear that specific interactions (which are used by natural enzymes) are missing from even the more sophisticated systems. This could be a problem if we want to mimic natural enzymes, or if we want to use (complex) model systems to understand the power of natural enzymes. But overall, there is no need for artificial design to replicate what we know about enzymes—artificial evolution might as well proceed toward a route unexplored by Nature. Although specific interactions are important for natural enzymes, or enzymes involved in metabolic pathways for which there needs to be discrimination, there are other processes for which such discrimination might not be crucial. Degradation of pollutants is an obvious... [Pg.93]

A typical chemical system is the oxidative decarboxylation of malonic acid catalyzed by cerium ions and bromine, the so-called Zhabotinsky reaction this reaction in a given domain leads to the evolution of sustained oscillations and chemical waves. Furthermore, these states have been observed in a number of enzyme systems. The simplest case is the reaction catalyzed by the enzyme peroxidase. The reaction kinetics display either steady states, bistability, or oscillations. A more complex system is the ubiquitous process of glycolysis catalyzed by a sequence of coordinated enzyme reactions. In a given domain the process readily exhibits continuous oscillations of chemical concentrations and fluxes, which can be recorded by spectroscopic and electrometric techniques. The source of the periodicity is the enzyme phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate by ATP, resulting in the formation of fructose-1,6 biphosphate and ADP. The overall activity of the octameric enzyme is described by an allosteric model with fructose-6-phosphate, ATP, and AMP as controlling ligands. [Pg.30]

The final challenge in modeling such systems will be to encapsulate an evolving ribozyme system [74,86,87] within vesicles formed from amphiphilic mixtures that are optimized for stability and permeability. It seems likely that one such mixture will have a set of properties that permit it to encapsulate a catalytic polymerase system and template, with sufficient permeability to allow substrate access to the enzyme at reasonable rates. Replication and ribozyme evolution would then occur in immensely large numbers... [Pg.24]


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