Eucatropine

Homatropine Produces mydriasis and cycloplegia Eucatropine Produces only mydriasis (Figure 14.6)... 

The action of eucatropine hydrochloride closely paralleh that of atropine, though it is much less potent than the latter It is used topically in a 0.1 mL dose as a mydriatic in 2 solution or in the form of small tablets. Use of concentralioit from 5 to 10% i.s. however, not uncommon. Dilation, vtiih... 

The mydriatic and cycloplegic activities of anticholinergics in humans are listed in Table 3.18. Atropine is recommended in situations requiring complete and prolonged relaxation of the sphincter of iris and the ciliary muscle. Mydriatics, like cyclopentolate, eucatropine, and homatropine bromide, with a shorter duration of action, are usually preferred for measuring refractive errors because of the relative rapidity with which their cycloplegic effects are terminated. 

Atropine sulfate Ipratropium bromide Mydriatic and Cyclopine Atropine sulfate Cyclopentolate hydrochloride Eucatropine hydrochloride Homatropine hydrobromide Scopolamine hydrobromide Tropicamide... 

Eucatropine is a synthetic muscarinic cholinergic receptor antagoifist. The various applications of synthetic muscarinic receptor antagonists are listed below ... 

Eucatropine (Euphthalmin) was the first successful mydriatic not containing the tropane nucleus it is the mandelic ester (VI) of the /3-form of 4-hydroxy-l, 2,2,6-tetramethylpiperidine. It is a relatively weak mydriatic and does not paralyze accommodation. The benzilic esters of both the a- and /3-forms of the same 4-hydroxypiperidine derivative, and their methochlorides, were prepared by Ford-Moore and Ing (36). The metho-salts were about 50 % more active than atropine in the mouse, but the more active /3-metho-salt proved to be a very weak mydriatic in man like eucatropine it was not cycloplegic. 

Baeyer, Villiger, Ber., 1898, 31, 2068. Eucatropine (Euphthdlmtne, betacaine man-delate)... 

---