Ethyleneglycol dimethacrylate EDMA

Conventionally, MlPs are obtained by bulk co-polymerization from a mixture consisting of a functional monomer, cross-linker, chiral template, and a porogenic solvent mixture. Nowadays, imprinting via non-covalent template binding is preferred over the covalent mode and involves three major steps (see Fig. 9.9). (i) Functional monomers (e.g. methacrylic acid, MAA) and a cross-linker (e.g. ethyleneglycol dimethacrylate, EDMA) assemble around the enantiomeric print molecule, e.g. (S)-phenylalanine anilide (1), driven by non-covalent intermolecular interactions, e.g. ionic interactions, hydrogen bonding, dipole-dipole interaction. Tr-rt-interaction. (ii) By thermally or photochemi-... 

The template, the functional monomers and the cross-linking monomers are dissolved in a non-polar solvent. The functional monomers and the template form complexes and the strength of these are reflected in the selectivity of the imprinted polymer. The choice of functional monomer is based on the template structure. Functional monomers are chosen for their ability to interact non-covalently with the template molecule. The most frequently used functional monomer so far is methacrylic acid (MAA). Also vinylpyridines have been frequently used. As cross-linking monomers, ethyleneglycol dimethacrylate (EDMA) or trimethylolpropane trimethacrylate (TRIM) are widely used. Several other types of functional and cross-linking monomers have been used in molecular imprinting experiments using the non-covalent approach. The choice of monomers is of course important to the... 

Scheme 3 Noncovalent imprinting of L-phenylalanine methyl ester in a methacrylic acid (MAA)/ethyleneglycol dimethacrylate (EDMA) polymer matrix. (View this art in color at www.dekker.com.)...

Figure 5 Selection of common cross-linkers used in molecular imprinting protocols. Both ethyleneglycol dimethacrylate (EDMA) and divinylbenzene (DVB) are very common crosslinkers in molecular imprinting. Other acrylate-based cross-linking monomers conunonly used include the branched cross-linker trimethylolpropane trimethacrylate (TRIM)-[24]. Among the water-soluble cross-linkers, there are phenylene-diacrylamide, V,V-methylene diacrylamide [22], and Z w-acryloylpiperazine [92], which have been used in aqueous systems for the imprinting of, e.g., enzymes.

Ethyleneglycol dimethacrylate (EDMA) SO mL tube with glass joint... 

Hattori and coworkers exploited both the living characteristics and photoactivation mechanism of STIMP to create MIPs consisting of methacrylic acid (MAA) and ethyleneglycol dimethacrylate (EDMA) synthesized from iniferter-modified cellulose membranes in the presence of theophylline, which served as the template molecule [76]. In addition to the ability to control polymer architecture, they observed that the STIMP photoactivation mechanism avoids template-monomer complexation, which is highly undesirable but usually observed in MIPs synthesized by thermally activated polymerization methods [76]. The MAA and EDMA comonomer system has also been used to synthesize MIPs from iniferter-modified carbon nanotubes... 

---