Urea ethyl

Phenyl-ethyl isothiocyanate. CgHj,(C.2H4)N C S, has been found in the oils of reseda root, nasturtium, and some varieties of Brassica. It is an oil of powerful odour, yielding a thiourea, melting at 137°. The latter body, when treated with silver nitrate and baryta water, yields phenyl-ethyl-urea, melting at 111° to 112°. 

Male Sprague-Dawley rats were administered lead acetate equivalent to 37 mg lead/kg/day in their drinking water for 76 weeks as part of a study to determine interactions between sodium nitrite, ethyl urea, and lead. There were no kidney tumors in the 10 control rats. Renal tubular carcinomas were found in 13 (81%) of the 16 treated rats. Three of these tumors were detected at 72 weeks and the remaining were found at terminal necropsy (Roller et al. 1985). 

Ethanol Diphenyl urea [l,l-Diphenyl 3 (2-hydroxy ethyl )-Urea 3-(2-hydroxyethyl)-l, 1-diphenylurea and 2-( 2-hydroxy ethyl)-1,1-diphenylurea (CA)],... 

Fig. 19. Synthesis of l-butyl-3-(2-thiophen-2-yl-ethyl)urea (41) and l-(3-isopr0PoX propyl)-3-phenethylthiourea (43).

A quantitative kinetic model of the polymerization of a-pyrrolidine and cyclo(ethyl urea) showed,43 that two effects occur the existence of two stages in the initiation reaction and the absence of an induction period and self-acceleration in a-pyrrolidine polymerization. It was also apparent that to construct a satisfactory kinetic model of polymerization, it was necessary to introduce a proton exchange reaction and to take into consideration the ratio of direct and reverse reactions. As a result of these complications, a complete mathematical model appears to be rather difficult and the final relationships can be obtained only by computer methods. Therefore, in contrast to the kinetic equations for polymerization of e-caprolactam and o-dodecalactam discussed above, an expression... 

Into a 3-necked spherical flask of 1 L provided with a dropping funnel, a condenser surmounted by a calcium chloride tube and a mechanical stirrer, is introduced a suspension of 17.6 g (0.2 mol) of ethyl urea in 150 ml of anhydrous benzene. There is added through the dropping funnel in 20 minutes a solution of 18.9 g (0.1 mol) a-chlorophenyl-acetyl chloride in 300 ml of benzene. The mixture is left at ambient temperature for 15 minutes and is then heated under reflux on the water bath with stirring for 5 hours. The benzene solution is decanted at elevated temperature in order to separate it from an oil deposited on the bottom of the flask, the benzene is driven off on the water bath, the last traces removed in vacuum, the crystalline residue is triturated in a mortar in about 200 ml of water, and the crystalline solid is separated off and is with water and dried in vacuum over phosphorus pentoxide. There are thus recovered 19.6 g (yield 82%) of l-(2-chloro-2-phenyl-acetyl)-3-ethyl-urea, which when recrystallized from 80 ml of benzene, takes the form of white crystals soluble in benzene but insoluble in water. The product has melting point 146°C. 

To a suspension of 39 g (0.163 mol) of l-(2-chloro-2-phenyl-acetyl)-3-ethyl-urea in 250 ml of anhydrous ethyl alcohol is added a sodium ethoxide solution containing 3.75 g (0.163 mol) of sodium dissolved in 250 ml of ethyl alcohol. The mixture is heated under reflux for 2 hours and left overnight at ambient temperature. The precipitated sodium chloride is separated off and copiously washed with alcohol. The alcohol is driven off from the filtrate on the water bath, the oily residue is triturated in 20 ml of iced water, and the solid formed is refrigerated for several hours, separated, washed with water and dried in vacuum over phosphorus pentoxide. The 5-phenyl-2-ethylamino-4-oxazolinone (fenozolone) obtained is recrystallized from anhydrous benzene. It then forms a white crystalline compound soluble in benzene and insoluble in water, MP 148°C. 

Parabanic Acid, the ureide of oxalic acid and oxidation product of uric acid obtained by the action of nitric acid, is converted into hydantoln and ethyl urea (Tafel and Reindl1). 

Plants. The primary metabolite, N-formyl-A -l-propyl-N-(2-(2,4,6-trichlorophenoxy)ethyl)urea, is formed from cleavage of the imidazole ring. This is degraded to N-propyl-jV-(2-(2,4,6-trichlorophenoxy)ethyl)urea, which occurs in both free and conjugated forms. Other metabolites include 2-(2,4,6-trichlorophenoxy)ethanol, 2-(2,4,6-trichlorophenoxy)acetic acid, traces of 2,4,6-trichlorophenol and conjugates of the above. Little unchanged prochloraz is present... 

SYNS ETHYLUREA N-ETHYLUREA UREA, ETHYL- UREA, 1-ETHYL-... 

Achiral lanthanide chelates can also be added to CSAs such as arylperfluoroalkyl-carbinols, the ethyl ester of 3,5-dinitrobenzoyl-L-leucine (25) , the 3,5-dinitrobenzoyl derivative of 1-phenylethylamine, Af-(l-(l-naphthyl)ethyl)trifluoroacetamide (26) and a series of l-(l-naphthyl)ethyl urea derivatives of amino acids (27) to enhance the enantiomeric discrimination. With sulfoxide or lactone substrates , the europium ion preferentially associates with the substrate in the bulk solution. Provided the enantiomers have different association constants with the CSA, the isomer that shows the weaker association with the CSA shows the larger lanthanide-induced shifts. Low concentrations of lanthanide relative to the substrate and CSA lead to enhancements of enantiomeric discrimination in the NMR spectrum. If the concentration of lanthanide is too high, binding of the substrate to the lanthanide strips the substrate from the chiral solvating agent and diminishes the chiral discrimination in the NMR spectrum. 

Crystals, mp 77-79. Soly in water is less than 1%, may be increased by the addition of solubilizers such as ethyl urea or propylene glycol Berger et at., U, S. pat. 2,468,423 (1949 to British Drug Houses). therap cat Topical antifungal. 

N-[(l-Acetoxy-2,2,2-trichloro)ethyl]urea 181 readily available from 180 and urea with Na-enolates of ketoesters followed by heterocyclization-dehydration gave 5-acyl-4-trichloromethyl-l, 2,3,4-tetrahydropyrimidi-nones 182, which then in the presence of NaH eliminates CHCI3 to give C-4 unsubstituted 183 (Scheme 69) (10T940). 

Koller, L.D., N.I. Kerkvliet, and J.H. Exon. 1985. Neoplasia induced in male rats fed lead acetate, ethyl urea, and sodium nitrite. Toxicol. Pathol. 13(l) 50-57. 

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