2-Ethyl-3-methyl-2- 3-nitro- -nitril

CN H9c4-i-S02- CH3 Na DMF -20 5 2-(4-Methyl-phenylsul-fonyl)-2-( 1-methyl-1-nitro-ethyl) -hexan-sdure-nitril 45b 77-79... 

Bei der Umsetzung von Butyl-(l-methyl-l-nitro-ethyl)-malonsaure-ethylester-nitril nach verschiedenen Methoden (A-E) fuhrt die Eliminierung in 64-83%iger Ausbeute zu 2-Isopropyliden-hexansaure-nitril3 (s.Tab. 44, S. 381 ff.) ... 

Azetidin 1 -(4-Acetamino-benzolsul-fonyl)-2-ethyl-3-oxo- E16c, 903 (aus R-S02-C-C0-CHN2) Butansaure 2,3-Dimethyi-2-(4-methyl-phenylsulfony])-3-nitro- -nitril E16d, 189 (C,C-Aufbau) Glutarsaure 2-(4-Methyl-benzol-sulfonylamino)- -1-methylester-5-nitril XV/1, 478 Pyrrol 2-Amino-3-methoxycarbo-nyl-l-(4-methyl-benzolsulfonyl)-... 

Rann et al. reported the dramatic influence of a new tailor-made, task-specific, and stable ionic liquid, butyl methyl imidazolium hydroxide ([bmim][OH]), in Michael addition. They have discovered that a task-specific ionic liqnid [bmim][OH] efficiently promoted the Michael addition of 1,3-dicarbonyl compounds, cyano esters, and nitro alkanes to a variety of conjugated ketones, carboxylic esters, and nitriles withont reqniring any other catalyst and solvent (Fig. 12.21) [16]. Very interestingly, all open-chain 1,3-dicarbonyl componnds such as acetylacetone, ethyl ace-toacetate, diethyl malonate, and ethyl cyanoacetate reacted with methyl vinyl ketone and chalcone to give the usual monoaddition products, whereas the same reactions with methyl acrylate or acrylonitrile provided exclusively bis-addition products. 

An iron-catalyzed multicomponent reaction forms poly-substituted pyridines in good yields (Scheme 5).The reaction involves a benzaldehyde, malono-nitrile, ethyl acetoacetate, and aniline in a nucleophilic addition followed by intermolecular cyclization. A number of groups are tolerated on the aldehyde including nitro, halogens, methyl, and methoxyls. Methyl and nitro groups were... 

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