3-ethyl-5-methoxy-2- 2,3-dihydro

H-Pyran, 2-alkoxy-4-methyl-2,3-dihydro-conformation, 3, 630 4H-Pyran, 2-amino-IR spectra, 3, 593 synthesis, 3, 758 4H-Pyran, 4-benzylidene-synthesis, 3, 762 4H-Pyran, 2,3-dihydro-halogenation, 3, 723 hydroboration, 3, 723 oxepines from, 3, 725 oxidation, 3, 724 reactions, with acids, 3, 723 with carbenes, 3, 725 4H-Pyran, 5,6-dihydro-synthesis, 2, 91 4H-Pyran, 2,6-diphenyl-hydrogenation, 3, 777 4H-Pyran, 6-ethyl-3-vinyl-2,3-dihydro-reactions, with acids, 3, 723 4H-Pyran, 2-methoxy-synthesis, 3, 762 4H-Pyran, 2,4,4,6-tetramethyl-IR spectra, 3, 593 4H-Pyran, 2,4,6-triphenyl-IR spectra, 3, 593... 

Reaction of 2,3-dihydro-3-hydroxy-3-methyl- 240 (R = Me), or a mixture of 2,3-dihydro-3-hydroxy-3-aryl-57/-pyrido[l,2,3-dfe]-l,4-benzoxazin-5-ones 240 (R = Ar) and (8-aroylmethoxy)quinolin-2(l//)-ones 241 (R = Ar) with ethyl 2-(bromomethyl)acrylate in the presence of activated Zn and hydroquinone gave 8-[(2,3,4,5-tetrahydro-4-methylidene-5-oxo-2-furanyl)-methoxy]quinolin-2(l//)-ones (242) (97HCA1161). 6,7-Dihydro derivatives of 240 reacted similarly (00HCA349). 

Chemicai Name N-[1-[2-(4-Ethyl-4,5-dihydro-5-oxo-1 H-tetrazol-1 -yOethyl] -4-(methoxy-methyl)-4-piperidinyl] -N-phenylpropaneamide hydrochloride... 

Chemical Name cis-(-t)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxy-phenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride... 

Chemical Name N-[(cyclohexylamino)carbonyl] -4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1 H)-isoquinolinyl)ethyl] benzenesulfonamide... 

CN ( )-6-(l,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester... 

CN L-valine 2-[(2-amino-l,6-dihydro-6-oxo-9//-purin-9-yl)methoxy]ethyl ester monohydrochloride... 

Qmino-l,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl N-[(benzyloxy)corbonyl]-L valinate (I)... 

US patent 6,713,481, Crystalline antifungal polymorph [104]. This patent discloses the crystalline polymorph Form I of ( )-4-[4-[4-[4-[[(2R-cA)-5-(2,4-difluoro-phenyl)tetrahydro-5-( 1H-1,2,4-triazol- l-ylmethyl)furan-3-yl]methoxy]phenyl]-1 -piper azinyl]phenyl-2,4-dihydro-2-[(S)-l-ethyl-2(S)-hydroxylpropyl]-3H-l,2,4-triazol-3-one,... 

Formation of mixtures of the above type, which is common with internal olefins, do not occur with many functionalized alkenes. Thus, tertiary cinnamates and cinnamides undergo cycloadditions with benzonitrile oxides to give the 5-Ph and 4-Ph regioisomers in a 25-30 75-70 ratio. This result is in contrast to that obtained when methyl cinnamate was used as the dipolarophile (177). 1,3-Dipolar cycloaddition of nitrile oxides to ethyl o -hydroxycinnamate proceeds regiose-lectively to afford the corresponding ethyl fra s-3-aryl-4,5-dihydro-5-(2-hydro-xyphenyl)-4-isoxazolecarboxylates 36 (178). Reaction of 4-[( )-(2-ethoxycarbo-nylvinyl)] coumarin with acetonitrile oxide gives 37 (R = Me) and 38 in 73% and 3% yields, respectively, while reaction of the same dipolarophile with 4-methoxy-benzonitrile oxide affords only 37 (R = 4-MeOCr>H4) (85%) (179). 

X = Cl 2-[2- (4-Chior-phenyt) -2-oxo-ethylidcn -1 -methyl-2,3-dihydro-benzimidazol (V) 42% X = OCH3 2-[2-(4-Methoxy-phenyl)-2-oxo-ethyl]-I-methyl-benzimidazol (VI) 40%... 

A dihydropyran may be an unstable intermediate and may be rapidly transformed to a pyran. Thus when 1-methoxy-1,3-butadiene underwent cycloaddition to ethyl pyruvate, a 45% yield of 2//-pyran 258b was isolated dihydro 257b195 was an intermediate. 

Ethyl 10-methoxy-7-propyl-4-oxo-4//-pyrimido[2,l-a]isoquinoline-3-carboxylate (100) was obtained from ethyl 7-allyl-10-methoxy-4-oxo-6,7-dihydro-4//-pyrimido[2,l-a]isoquinoline-3-carboxylate (99) by heating in boiling p-cymene in the presence of 10% Pd/C catalyst for 4 h (78USP 4127720). 

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