Ethyl isobutyrylisobutyrate

Ketonic hydrolysis with a mixture of sulphuric and acetic acids of the ethyl isobutyrylisobutyrate yields di-tso-propyl ketone ... 

Ethyl isobutyrylisobutyrate. Add 24-6 g. (28-3 ml.) of ethyl iso-butyrate, b.p. 110-111°, to the solution of ca. 0 21 mol of sodium triphenyl-methide in approximately 1400 ml. of ether contained in the 2-litre conical flask. Stopper the flask, shake well to effect complete mixing, and keep at room temperature for 60 hours. Acidify the reaction mixture by adding, with shaking, 15 ml. of glacial acetic acid, and then extract with 100 ml. of water. Wash the ethereal solution with 50 ml. portions of 10 per cent, sodium carbonate solution until free from excess acid, dry over anhydrous magnesium sulphate, and distil off the ether on a steam bath. Distil the residue under reduced pressure from a Claisen flask with fractionating side arm (Figs. II, 24, 4—5). Collect the ethyl isobutyryl isobutyrate at 95-96°/18 mm. the yield is 15 g. The b.p. at atmospheric pressure is 201-202°. 

The base is useful for promoting sterically hindered condensations, for example ethyl isobutyrate---> ethyl isobutyrylisobutyrate (30%). It is useful for effecting... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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