Ethyl 9-fluoro-10-

Ethyl 2-fluoro-2-(4-tolyl)acetate (15) Typical Procedure 30... [Pg.541]

A solution of mixed A. jV-diethyl-l,l,2,3,3,3-hexafluoropropanamine (10) and 11 (2.2 g, 10 mmol) in CH,C12 (15 mL) was added dropwise to a solution of ethyl 2-hydroxy-2-(4-tolyl)acetate (14 0.78 g, 4 mmol) in CH2C12 (20 mL) at rt. After stirring for 24 h, the mixture was poured into H20 and was extracted with i-Pr20. The combined organic layers were washed with H20, dried (Na,CO,) and concentrated. The residue was subjected to column chromatography (silica gel, hexane/EtOAc 9 1). The first elution gave ethyl 2-fluoro-2-(4-tolyl)acetate (15) yield 0.47 g (60%). [Pg.541]

Propanoate Ethyl 2-Fluoro-2-nitro-ElObj. 3.36 (Educt)... [Pg.617]

C,HI5FO, (Continuation) Hexanoate Ethyl 2-Fluoro-2-methyl-... [Pg.668]

Ethyl 2-Fluoro-2-nitrosooxy-3-oxo-3-phenyl- ElOa, 266 (11 -+ F) Ethyl 2-Fluoro-3-(4-nilro-pheny])-3-oxo- ElOa, 489 (H -> F)... [Pg.683]

A patent describes the synthesis of ethyl 2-fluoro-2-methylpropanoate (9) from ethyl 2-hydroxy-... [Pg.83]

Ethyl 2-Fluoro-2-methy]propaii(>atc (9) Typical Procedure ... [Pg.83]

The alkylation of the enolate derived from ethyl 2-fluoro-2-phenylselanyl propanoate, followed by an oxidative deselenenylation, allowed the stereoselective synthesis of ( )-a-fluoro-a, -unsaturated esters [47] (Scheme 38). [Pg.130]

The E-selective Horner-Wittig reactions of ethyl 2-fluoro-2-diethyl-phosphonoacetate (441) with 2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-l-yl)cyclopentanone (442) furnished the corresponding tetra-substituted fluoroolefin (443), the key substrate in synthesis of / flC-Ar-Cbz-Gly- P[(E)-CF=C]-Pro-OH dipeptide isostere (444) (Scheme 134). ... [Pg.284]

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