Ethers, methyl synthesis

A Methylamino)phenol. This derivative, also named 4-hydroxy-/V-methy1ani1ine (19), forms needles from benzene which are slightly soluble in ethanol andinsoluble in diethyl ether. Industrial synthesis involves decarboxylation of A/-(4-hydroxyphenyl)glycine [122-87-2] at elevated temperature in such solvents as chlorobenzene—cyclohexanone (184,185). It also can be prepared by the methylation of 4-aminophenol, or from methylamiae [74-89-5] by heating with 4-chlorophenol [106-48-9] and copper sulfate at 135°C in aqueous solution, or with hydroquinone [123-31 -9] 2l. 200—250°C in alcohoHc solution (186). 

Methyl chloride can be converted iato methyl iodide or bromide by refluxing ia acetone solution ia the presence of sodium iodide or bromide. The reactivity of methyl chloride and other aUphatic chlorides ia substitution reactions can often be iacteased by usiag a small amount of sodium or potassium iodide as ia the formation of methyl aryl ethers. Methyl chloride and potassium phthalimide do not readily react to give /V-methy1phtha1imide unless potassium iodide is added. The reaction to form methylceUulose and the Williamson synthesis to give methyl ethers are cataly2ed by small quantities of sodium or potassium iodide. 

Sridharan V, Avendano C, Menendez JC (2007) CAN-catalyzed three-component reaction between anilines and alkyl vinyl ethers stereoselective synthesis of 2-methyl-1,2,3,4-tetrahydroquinolines and studies on their aromatization. Tetrahedron 63 673-681... 

Methyl fert-butyl ether (MTBE) synthesis 69,70 SMBCR... 

Synthesis solvents, such as dichloromethane (DCM), dimethoxyethane (DME), acetic acid (AcOH), ethyl acetate (EtOAc), fe/t-butanol (f-BuOH), 1-methyl-2-pyrrolidinone (NMP), tetrahydrofurane (THF), methanol (MeOFl), toluene, benzene, A N -dimethylformamide (DMF), methyltertbutylether (MTBE), hexane, dimethylsulfoxide (DMSO), and diethyl ether, were synthesis or peptide synthesis grade (if necessary) and can be obtained from Sigma-Aldrich, Fisher, VWR, or other commercial sources. 

Yang et al. (2003) used bis(methylsulfonoxy-methyl)ether for synthesis of already known reactivators (obidoxime, HI-6, 14d) as shown (Figure 66.21). No biological data of synthesized compoimds were mentioned in the article. 

The hydrogenation of carbon dioxide was studied using composite catalysts comprised of Fe-Zn-M (M= Cr, Al, Ga, Zr) catalysts and the HY zeolite, where the methanol synthesis and the methanol-to-gasoline(MTG) reaction are combined. The results show that light olefins are important intermediates for iso-butane formation. In all of the cases, the selectivity of isobutane, which can be used as a reactant in subsequent methyl-tert-butyl ether (MTBE) synthesis, was the highest in hydrocarbons. 

Thiopyrilium salts, dichloromethyl methyl ether in synthesis of 78ZC2O1. 

AI3-16096 Anesthenyi Bis(methoxy)methane Dimeth-oxymethane Dimethyl formal 2,4-Dioxapentane EINECS 203-714-2 Formal Formaldehyde dimethyl-acetal Formaldehyde methyl ketal HSDB 1820 Methane, dimethoxy- Methoxymethyl methyl ether Methylal Methylene dimethyl ether Metylal UN1234, Used as a solvent In organio synthesis perfumes, adhesives, protective coatings special fuel. Liquid mp = -104.8° bp = 42° d = 0.8593 soluble in H2O (30 g/100 ml), very soluble In EtOH, Et20, MezCO, CeHe LD50 (rbt orl) n5708mg/kg. 

AI3-18132 Cyclohexane, methyl- Cyclohexylmethane EINECS 203-624-3 Hexahydrotoluene HSDB 98 Methylcyclohexane Metylocykloheksan NSC 9391 Sextone B Toluene hexahydride Toluene, hexahydro- UN2296. Solvent for cellulose ethers, organic synthesis. Liquid mp = -126.6° bp = 100.9° 6 = 0.7694 insoluble in H2O, soluble EtOH, Et20, freely soluble in MezCO, CeHe, CCI4, ligroin. LDso (mus orl) = 2250 mg/kg. Janssen Chimica Renta Mfg. Phillips 66. 

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