Ether narcosis

Sections and all measurements after a single dose were carried out after 2, 4, 12, 24, 48, 72 and 120 hours following injection of the compounds. In the case of 3-7 fold administration, the animals were sacrificed 24 hours after the last dose. Rats were sacrificed under ether narcosis, mice - by dislocation of the spinal cord. Then livers and blood from heart were collected. 

EAT-cells were maintained by serial transfer through peritoneal cavities of 7-9 week-old Balb-C mice with an average weight of 25 g. Four days after transplantation of the tumor, animals received an ip injection of cytoxan (Asta Werke), a metabolically activated chemotherapeutic, at a dose of 8 to 16 p.g/g body wt. Immediately after, when required, caffeine at 130 ig/g body wt was also injected ip. One hr later animals were injected ip with 1 ml BdUrd-activated charcoal (Sigma and Merck, respectively) suspension with a BdUrd dose of 1 mg/g body wt. Prior to harvest animals were treated for 2 hr with 0.1 ml of 1 mg/ml colchicine (Sigma). Animals were sacrificed by ether narcosis after 26 or 48 hr. Cells were washed once with 0.075 M KCl and treated with the same hypotonic solution for 25 min. They were fixed with methanol glaciahacetic acid 3 1 and air dried. The... 

Inhalation is the most common means by which ethers enter the body. The effects of various ethers may include narcosis, irritation of the nose, throat, and mucous membranes, and chronic or acute poisoning. In general, ethers are central nervous system depressants, eg, ethyl ether and vinyl ether are used as general anesthetics. 

Narcosis Narcosis is a state of deep stupor or unconsciousness, produced by a chemical substance, such as a drug or anesthesia. Inhalation of certain chemicals can lead to narcosis. For example, diethyl ether and chloroform, two common organic solvents, were among the first examples of anesthesia known. Many other chemicals that you would not suspect can also cause narcosis. For example, even though nitrogen gas comprises 80% of the air we breathe and is considered chemically inert (unreactive) it can cause narcosis under certain conditions. Always work with adequate inhalation and avoid inhaling chemical fumes, mists, dusts etc. whenever possible. Use fume hoods and respirators as necessary. 

At the end of the war, he returned to Munich as Associate Professor and Director of the Laboratory of Organic Chemistry. The Department was then under Richard Willstatter s direction, and Meyer occupied the same position as the one held for many years by Willstatter under Baeyer s leadership. He resumed his investigation on keto-enol tautomerism, and, in collaboration with H. Hopff, isolated by distillation the pure enol form of ethyl acetoacetate. Other work from the same period included an examination of the action of nitric acid on phenol and phenol ether (with W. Reppe and W. E. Elbers), and a study of narcosis (with H. G. Billroth)— an extension of his father s work. 

Toxicology. Allyl glycidyl ether (AGE) causes skin, eye, and upper respiratory tract irritation and contact dermatitis high concentrations cause pulmonary edema and narcosis, whereas chronic exposures induce nasal lesions in animals. 

Toxieology. Dichloroethyl ether is a severe respiratory and eye irritant high levels cause narcosis in animals, and severe exposure is expected to cause the same effects in humans. The inhalation hazard is limited by its relatively low volatility skin absorption is more hazardous. 

Toxicology. Dipropylene glycol methyl ether (DPGME) at very high concentrations causes narcosis in animals, and it is expected that severe exposure will produce the same effect in humans. Because the propylene glycol ethers are metabolized differently from the ethylene glycol ethers, they are not associated with potent teratogenic, spermatotoxic, or hematopoietic effects. ... 

Toxicology. Ethyl ether causes eye and respiratory irritation, and, at high concentrations, it produces central nervous system depression and narcosis. 

Higher concentrations of dimethyl ether act on the central nervous system to produce narcosis. The effects are rapidly reversible which is consistent with the very rapid bioelimination of the molecule. Dimethyl ether has in the past been considered for use as a human anesthetic. It should be noted that this chemical can produce cardiac sensitization similar to the effects of epinephrine. 

USE For preparing spirit nitrous ether by mixing with 21 parts alcohol by weight. Caution May cause methemoglobinemia and hypotension and, in high conens, narcosis. 

Properties Colorless clear liq., benzene odor sol. in alcohol, benzene, ether, acetone, chloroform, petrol, ether, ethyl acetate misc. with most org. soivs. very si. sol. in water m.w. 92.13 dens. 0.866 (20/4 C) vapor pressure 36.7 mm Hg (30 C) m.p. -94.5 C b.p. 110.7 C flash pt. (CC) 4.4 C ref. index 1.4967 (20 C) KB value 105 Toxicology ACGIH TLV/TWA 100 ppm STEL 150 ppm LD50 (oral, rat) 7.53 g/kg, (skin, rabbit) 12,124 mg/kg toxic by ing., inh., IP, and skin absorption irritant to eyes, skin, respiratory tract severe dermatitis on direct contact ing. may cause lung aspiration overexposure by inh. may cause CNS excitation/depression high cones, may cause paresthesia, vision disturbances, dizziness, nausea, headache, narcosis, death experimental teratogen. 

Properties Colorless clear volatile liq. or gas nearly odorless < 20% cone., faint sweet odor at high cones. sol. in alcohol, ether insol. in water m.w. 137.4 sp.gr. 1.494 (liq., 17.2 C) f.p. -111 C b.p. 23.7 C ref. index 1.379 surf. tens. 18 dynes/cm dielec, const. 2.303 noncombustible Toxicology ACGIH TLV/CL 1000 ppm LD50 (IP, mouse) 1743 mg/kg TDLo (inh., human, 30 min) 50,000 ppm poison by inh. mod. toxic by IP route human systemic effects CNS effects > 1% cone. can cause narcosis and anesthesia in humans severe exposure can cause nausea, vomiting, irregular heartbeat, cardiac arrest, death TSCA listed Precaution Incompat. with reactive metals, e.g., powd. aluminum, sodium, potassium (can react violently), lithium (can detonate)... 

Ether extracted with equal volume of lithium hydroxide, aqueous phasepolarographed.(l)Ordinary ether (2) distilled ether (3) ether for narcosis. I and II peroxides. III aldehydes. Curves starting at 0 V, Hg-pool electrode, 200 mV/absc., fidl scale sensitivity 20 /aA. 

Narcosis is a reversible state of arrested activity of protoplasmic structures caused by a wide variety of organic chemicals. Veith et al. (1983) demonstrated that this non-specific mode of action was responsible for lethality in the fathead minnow (Pimephales promelas) by alcohols, ketones, ethers, alkyl halides, and many benzene derivatives. The structure-toxicity relationships... 

Non-polar narcosis Saturated alkanes with, for example, halogen and/ or alkoxy substituent (aliphatic alcohols, ketones, ether, amines) halogens and alkyl substituted benzenes... 

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