Estrogens antineoplastic

Bicalutamide may increase the effect of oral anticoagulants. Flutamide enhances the action of leuprolide. Additive antineoplastic effects may occur when leuprolide is administered with megestrol or flutamide. Estrogens decrease the effectiveness of tamoxifen. 

Some tumors are estrogen-dependent and the use of an antiestrogen has therapeutic value. One such antineoplastic agent appears to be patterned after clomiphene. Complex aryl ketone 204 is treated with phenyl magnesium chloride and the resulting tertiary... 

Estradiol Depo-Estradiol, Estrace, Estraderm, Vivelle, many others Estrogen replacement, antineoplastic, prevention of osteoporosis... 

Ethinyl estradiol Estinyl Estrogen replacement, antineoplastic... 

The mean uses per compound in Table V is 1.7. The mean uses per compound can be counted tor each ot the uses, it was shown (9) that mean uses per compound is distributed statistically and the outliers on each side could be identified. The ones with low mean uses per compound were highly specific uses such as antimicrobial, antineoplastics, antihistaminics, estrogenics, etc. The ones with high mean uses were the ones which were present in dominant use pairs or clusters such as diuretics, vasodilator, CNS depressant, etc., or which had old imprecise use descriptors such as sudorific, diaphoretic, dermatoses, etc. 

They have estrogenic activity where optically active forms are more potent and they have antineoplastic activity. [Aboul-Enein et al. Anal Profiles Drug Subst 11 347 1982, J Am Chem Soc 65 4917947.]... 

Estrogen, possessing antineoplastic and antiosteoporotic properties, is indicated in abnormal uterine bleeding (hormonal imbalance), in castration, primary ovarian failure, and osteoporosis, in female hypogonadism, in menopausal symptoms, atrophic vaginitis, or kraurosis vulvae, in prostatic cancer, and in breast cancer (see also Figure 48). 

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