Estradiol urinary excretion

Spironello-Vella, E. and deCatanzaro, D. (2001) Novel male mice show gradual decline in the capacity to disrupt early pregnancy and in urinary excretion of testosterone and 17 beta-estradiol during the weeks immediately following castration. Horm. Metab. Res. 33, 681-686. 

Conversion of androstenedione to estrone and of testosterone to estradiol by peripheral tissue (fat cells) rather than liver probably explains the increased urinary excretion of estrogen in patients with liver cirrhosis. 

In a landmark study of the effect of boron on steroid hormone metabolism (Nielsen et al., 1987), postmenopausal women lived in a metabolic ward under controlled conditions for 167 days. For the first 119 days, the participants were fed basal diets, which provided 0.25 mg boron/day. The interventions also included dietary periods of magnesium and aluminum suppl entation. In two additional dietary periods, a subsample of the women was provided with a boron supplanent of 3 mg/ day. The study demonstrated, for the first time, that supplementation of postmenopausal women with a low dose (3 mg/day) of boron increases significantly the plasma concentrations of 17b-estradiol and testosterone. The study showed also that boron suppl entation decreases significantly the urinary excretion of calcium and magnesium. 

Reifenstein and Dempseyl9 using Talbot s colorimetric method found the urinary "estrone" to vary from 10 to 39 ig. per day in 5 normal women and from 27 to 40 ig. per day for 5 normal men. Attention was not paid to the question of whether the observed differences were primarily inter-individual. In another study20 involving 3 men and 2 women, Pincus found about a 12-fold variation between the two women. One woman excreted over a period of several days estradiol + estrone + estriol to the extent of 155.2 ig. per day for the other woman and the 3 men, the corresponding values were respectively 13.4 ig., 12.4 ig., 7.6 ig. and 16.8 ig. 

The excretion profile of estrogens in menstruating women with normal cycles is reflected in either plasma estradiol-17 S or urinary levels. However, with clinical problems such as polycystic ovarian disease, the extraovarian production of estrogens is best evaluated using urine specimens. 

Munro CJ, Stabenfeldt GH, Cragun JR, Addiego LA, Overstreet JW, Lasley BL. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabohtes as measured by enzyme immunoassay and radioimmunoassay. Clin Chem 1991 37 838-44. 

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