Estimating Effective Intestinal Permeability Coefficient Using a Mass Balance Approach

Estimating Effective Intestinal Permeability Coefficient Using a Mass Balance Approach 

At steady state, the following mass balance can be applied across a perfused segment of the intestine. The rate of mass entering and exiting the intestinal segment (i.e. cylindrical tube) is the product of the volumetric flow rate (Q) and either inlet concentration (Cin) or outlet concentration (Cout), respectively. Assuming that mass is lost from the tube only by absorption into the blood, the mass absorbed per unit time is the difference between the rates of mass flow in and out of the tube as follows  

Rate of mass in - Rate of mass out = Rate of mass absorbed 

Estimating the term (i.e. bulk drug concentration profile in an intesti- 

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