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Esters malonic ester synthesis

Derivatives of a-anions of esters Malonic ester synthesis... [Pg.25]

By the malonic ester synthesis (compare Section 111,165), for example ... [Pg.753]

The thermal decarboxylation of malonic acid derivatives is the last step m a multistep synthesis of carboxylic acids known as the malonic ester synthesis This synthetic method will be described m Section 21 7... [Pg.818]

The malonic ester synthesis is a method for the preparation of carboxylic acids and is represented by the general equation... [Pg.897]

The malonic ester synthesis is conceptually analogous to the acetoacetic ester synthesis The overall transformation is... [Pg.897]

The properties of diethyl malonate that make the malonic ester synthesis a useful procedure are the same as those responsible for the synthetic value of ethyl acetoacetate The hydrogens at C 2 of diethyl malonate are relatively acidic and one is readily removed on treatment with sodium ethoxide... [Pg.897]

Among the methods for preparing carboxylic acids carboxylation of a Grignard reagent and preparation and hydrolysis of a nitrile convert RBr to RCO2H The malonic ester synthesis converts RBr to RCH2CO2H... [Pg.897]

In a typical example of the malonic ester synthesis 6 heptenoic acid has been pre pared from 5 bromo 1 pentene... [Pg.898]

By performing two successive alkylation steps the malonic ester synthesis can be applied to the synthesis of a a disubstituted derivatives of acetic acid... [Pg.899]

The malonic ester synthesis has been adapted to the preparation of cyclo alkanecarboxyhc acids from dihaloalkanes... [Pg.899]

Section 21 7 The malonic ester synthesis is related to the acetoacetic ester synthesis Alkyl halides (RX) are converted to carboxylic acids of the type RCH2COOH by reaction with the enolate ion derived from diethyl mal onate followed by saponification and decarboxylation... [Pg.907]

The most widely used method for the laboratory synthesis of a ammo acids is a modification of the malonic ester synthesis (Section 21 7) The key reagent is diethyl acetamidomalonate a derivative of malonic ester that already has the critical nitrogen substituent m place at the a carbon atom The side chain is introduced by alkylating diethyl acetamidomalonate m the same way as diethyl malonate itself is alkylated... [Pg.1122]

Malonic ester synthesis (Section 21 7) Synthetic method for the preparation of carboxylic acids involving alkylation of the enolate of diethyl malonate... [Pg.1288]

The synthetic importance of the malonic ester synthesis follows from the fact that the substituted malonic ester can easily be hydrolyzed, and subsequently decarboxylates to yield a substituted acetic acid 9. This route to substituted acetic acids is an important method in organic synthesis ... [Pg.192]


See other pages where Esters malonic ester synthesis is mentioned: [Pg.522]    [Pg.523]    [Pg.897]    [Pg.897]    [Pg.899]    [Pg.897]    [Pg.897]    [Pg.899]    [Pg.190]    [Pg.190]    [Pg.191]    [Pg.192]    [Pg.193]    [Pg.262]    [Pg.856]   
See also in sourсe #XX -- [ Pg.269 , Pg.270 , Pg.271 , Pg.348 ]

See also in sourсe #XX -- [ Pg.269 , Pg.270 , Pg.271 , Pg.348 ]

See also in sourсe #XX -- [ Pg.789 , Pg.790 ]

See also in sourсe #XX -- [ Pg.1059 , Pg.1062 ]

See also in sourсe #XX -- [ Pg.271 , Pg.272 ]

See also in sourсe #XX -- [ Pg.900 , Pg.901 , Pg.902 ]




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Acetic acid malonic ester synthesis

Alkyl halide malonic ester synthesis with

By the malonic ester synthesis

Carbonyl compounds malonic ester synthesis

Carboxylic acid malonic ester synthesis

Carboxylic acids by malonic ester synthesis

Cyclization malonic ester synthesis of cyclobutane

Decarboxylation malonic ester synthesis

Diethyl malonate in malonic ester synthesis

Enolate anions malonic ester synthesis

From malonic ester acid synthesis

Gabriel-malonic ester synthesis

Magnesium in malonic ester synthesis

Malonate ester synthesis

Malonate ester synthesis

Malonate esters

Malonic ester acid synthesis

Malonic ester syntheses Malononitrile

Malonic ester synthesi

Malonic ester synthesi

Malonic ester synthesis

Malonic ester synthesis

Malonic ester synthesis acylation by o-nitrobenzoyl chloride

Malonic ester synthesis arylation

Malonic ester synthesis intramolecular

Malonic ester synthesis of carboxylic acids

Malonic ester synthesis of substituted acetic

Malonic ester synthesis of substituted acetic acids

Malonic ester synthesis, modifie

Malonic ester—

Malonic synthesis

Organic synthesis malonic ester

Preparation malonic ester synthesis

Retrosynthetic analysis malonic ester synthesis

Sodium ethoxide in malonic ester synthesis

Sodium ethoxide malonic ester synthesis

The Malonic Ester Synthesis

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