Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Ester-containing linker

The main advantage of ferr-alkyl esters as linkers is their stability towards nucleophiles. For instance, no diketopiperazine formation is observed during the preparation of peptides containing carboxy-terminal proline, an otherwise common side reaction when using benzyl alcohol linkers (Section 15.22.1). [Pg.44]

NHS- or sulfo-NHS ester-containing homobifunctional cross-linkers react with... [Pg.210]

Another multifunctional amide-containing linker has also been published recently by Abell et al. [180]. The synthesis of the new anthracenyl-based linker 168 involves again four synthetic steps in solution phase that can be conducted in 53% overall yield. Different to the other linker strategies is the attachment to the resin because the linker core and the substrate are connected in solution phase and are afterwards linked to a maleimide-polystyrene resin. To prove the utility of the new resin, N- and 0-nucleophiles were added to give amides 171, esters 170 and carboxylic acids 169 (Scheme 26). [Pg.23]

As of this writing (1997), researchers are exploring combinations of acids, additives, and catalysts to achieve a suitable economic finish. However, commercial appHcation of these finishes would require costs akin to that of DMDHEU as well as compliance with formaldehyde release levels by consumers, regulators, and the textile industry. Another possible impetus could be marketing considerations. Nevertheless, this work has sparked intense effort in the use of cross-linkers containing ester cross-links and has broadened the scope of cross-linker research. [Pg.447]

An exo-linker according to Fig. 10.1 must contain an enzyme labile group R, which is recognized and attacked by the biocatalyst Possible combinations could be phenylacetamide/penicillin amidase, ester/esterase, monosaccharide/glycosid-ase, phosphate/phosphatase, sulfate/sulfatase and peptides/peptidases [41]. The following systems have been worked out (Tab. 10.2). [Pg.458]

Suitably protected amino acids (112) (cysteine, serine, and lysine) have been added via the side-chain heteroatom (S, O, and N, respectively) to conjugated alkynones, alkynoic ester and alkynoic amide (113). The expected heterosubstituted vinyl product (114) was formed in each case, mainly as the ii-isomer. In an accompanying paper, this type of addition was applied to the derivatives of fluorescein, 7-hydroxycoumarin, Sudan 1, and dansyl chloride with linker arms containing a conjugated terminal alkyne. [Pg.438]

To examine the second way of binding the chloro ester 1-Me to a polymer as in 268 (Fig. 12), the TentaGel-S-COOH resin 279 which contains a succinyl linker, was esterified with the 2 -(4-hydroxybutyl)-substituted chloro ester 280 (prepared by debenzylation of compound 2l-Me) (Scheme 81) [11b]. Only the Michael addition of secondary amines onto 281 and the removal of the adducts 283 from the resin has been probed so far, any further transformations of polymer-bound compounds 281 need yet to be developed. [Pg.218]

The two main resin linkers developed so far are shown in Scheme 18, i.e. tris(alk-oxy)benzylamide- 412 and 4-alkoxybenzylamide-type linkers)341 the former being TFA labile and thus fully compatible with Fmoc/tBu and the latter strongly acid labile and correspondingly compatible with Boc/Bzl chemistry. As shown in the case of the tris(alk-oxy)benzaldehyde handle such handles may be introduced into the C-terminal amino acid ester by reductive amination, and after suitable N -protection coupled to amino-functionalized resins (see Scheme 18). Alternatively, the tris(alkoxy)benzaldehyde-functionalized resin, BAL resin, (see Scheme 14) is used to link the C-terminal amino acid ester by reductive amination. To overcome the difficult acylation of the V -arylamino acid ester derivative on resin (best results with 10 equivalent symmetrical anhydrides), synthesis in solution of the C-terminal dipeptide building block containing the amide handle followed by its attachment to the resin has been proposed)341 ... [Pg.498]


See other pages where Ester-containing linker is mentioned: [Pg.671]    [Pg.671]    [Pg.48]    [Pg.210]    [Pg.210]    [Pg.211]    [Pg.456]    [Pg.236]    [Pg.88]    [Pg.187]    [Pg.277]    [Pg.1819]    [Pg.420]    [Pg.674]    [Pg.56]    [Pg.190]    [Pg.190]    [Pg.436]    [Pg.36]    [Pg.225]    [Pg.180]    [Pg.515]    [Pg.221]    [Pg.346]    [Pg.639]    [Pg.185]    [Pg.119]    [Pg.15]    [Pg.240]    [Pg.768]    [Pg.1012]    [Pg.181]    [Pg.533]    [Pg.137]    [Pg.153]    [Pg.154]    [Pg.287]    [Pg.301]    [Pg.495]    [Pg.251]   
See also in sourсe #XX -- [ Pg.671 ]




SEARCH



Esters containing

Linker ester

© 2024 chempedia.info