Escherichia coli phospholipid synthesis

The primary consideration in the genesis of any biological membrane is the location of the synthetic apparatus that manufactures the subunits of the membrane and its relationship to the final distribution of its products [13], In Escherichia coli, substantial evidence indicates that the synthesis of phospholipids occurs at the inner (cytoplasmic) membrane by enzymes that have their active sites on the cytoplasmic surface of the inner membrane. Such an orientation allows free access of water-soluble substrates and reaction products to the cytosol. 

Furrow, M. H., Pizer, L. I. Phospholipid synthesis in Escherichia coli infected with T4 bacteriophages. J. Virol. 2, 594-605 (1968). 

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