Erythropoietin-Epoetin Alpha

Podesta A, Carmagnini E, Parodi E, Dottori V, Crivellari R, Barberis L, Audo A, Lijoi A, Passerone G. Elective coronary and valve surgery without blood transfusion in patients treated with recombinant human erythropoietin (epoetin-alpha). Minerva Cardioangiol 2000 48(ll) 341-7. [Pg.1249]

Veys N, Dhondt A, Lameire N. Pain at the injection site of subcutaneously administered erythropoietin phosphate-buffered epoetin alpha compared to citrate-buffered epoetin alpha and epoetin beta. Chn Nephrol 1998 49(1) 41. ... [Pg.1252]

Erythropoietin is a glycoprotein (Epoetin alpha), a 165 amino acid glycoprotein with MW of 30,400 Da. [Pg.340]

The human gene for erythropoietin, a hormone produced in the kidney, was first cloned in the 1980s (Jacobs et al, 1985), and the recombinant form was developed soon after that (Flaherty etal, 1989). The recombinant alpha form of erythropoietin, epoetin, is now very widely used in the context of the anaemia associated with... [Pg.451]

Recombinant DNA technology products aldesleukin (IL-2, used in renal cancer) erythropoietin (epoetin alfa, used in anemias) filgrastim (G-CSF, used in neutropenia) interferon alpha (used in hepatitis B and C and in cancer), interferon beta (used in multiple sclerosis) interferon gamma (used in chronic granulomatous disease) oprelvekin (IL-11, used in thrombocytopenia) thrombopoietin (used in thrombocytopenia) and sargramostim (GM-CSF, used in neutropenia). [Pg.553]

Epoetin alpha (e.g., Epogen) Epoetin alpha is recombinant human erythropoietin. Erythropoetin, which is synthesized in the kidney in response to hypoxia or anemia, stimulates erythropoiesis. Epoetin alpha is indicated for anemia in patients with chronic renal failure, because these patients are unable to synthesize erythropoetin to correct the anemia. Additional uses include correcting zidovudine (AZT)-induced anemia in HIV-infected patients and chemotherapy-induced anemia in cancer patients (unlabelled use). Several weeks of therapy are required before the hematocrit levels rise, therefore, this drug cannot replace transfusions for the acute treatment of severe anemia. Epoetin alpha should not be used in patients with uncontrolled hypertension because the elevation in hematocrit may exacerbate hypertension. [Pg.84]

Epoetin alfa [FDA CAS USAN INN BAN] 1-165-Erythropoietin (human clone lambda HEPOFL13 protein moiety) [CAS] 1-165-Erythropoietin (human clone lambdaHEPOFL13 protein moiety), glycoform alpha [CAS]... [Pg.506]

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