Erythromycin ethyl succinate

Ofloxacin 300 mg orally twice daily for 7 days, or levofloxacin 500 mg orally once daily for 7 days, or erythromycin base 500 mg orally four times daily for 7 days, or erythromycin ethyl succinate 800 mg orally four times daily for 7 days Erythromycin base 250 mg orally four times daily for 14 days, or erythromycin ethyl succinate 800 mg orally four times daily for 7 days (or 400 mg orally four times daily for 14 days... 

The oral dosage of erythromycin base, stearate, or estolate is 0.25-0.5 g every 6 hours (for children, 40 mg/kg/d). The dosage of erythromycin ethyl succinate is 0.4-0.6 g every 6 hours. Oral... 

Tablets (e.g., quinapril hydrochloride) Capsules (e.g., pancrease) Oral suspensions (e.g., cefuroxime axetil) Injectables (e.g., coumadin) Sterile powders (e.g., cefoxitin) Topicals (e.g., zinc oxide powder) Anti-infectives (e.g., erythromycin ethyl succinate) Anti-coagulants (e.g., warfarin sodium) Anti-asthmatics (e.g., montelukast sodium) Anti-psychotics and anxiolytics Hypnotics and anticonvulsants (e.g., barbiturates) Anti-hypertensives Anti-inflammatories (e.g., indomethacin) Analgesics (e.g., aspirin) Antacids (e.g., aluminum hydroxide) Diuretics Enzymes (e.g., pancreatin) Hormones...

MW 733), erythromycin estolate (Er-E, MW 789), and erythromycin ethyl succinate (Er-S, MW 789) was analyzed using HSCCC-ESI-MS with a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (4 7 4 3). TIC showed, clearly, four peaks corresponding to Er-A, Er-E, Er-S, and an unknown substance. The mass spectra of Er-E and Er-S gave [M + H]+ at miz 862 and 789 and [M -i- H H2O... 

Sample preparation Weigh out materied corresponding to ca. 250 mg erythromycin ethyl-succinate, add 10 mL acetone, sonicate 5 min, centrifuge at 2500 g for 5 min, dilute a 6 mL aliquot of supernatant to 10 mL with 200 mM pH 6.5 tetrabutylammonium hydrogen sulfate 200 mM pH 6.5 phosphate buffer. water 12.5 7.5 80. 

Erythromycin ethyl succinate is a mixed double ester pro-drug in which one carboxyl of succinic acid esterifies the C-2 hydroxyl of erythromycin and the other ethanol (Fig. 38.28). This pro-drug frequently is used in an oral suspension for pediatric use largely to mask the bitter taste of the drug. Film-coated tablets also are used to deal with this. Some cholestatic jaundice is associated with the use of EES. 

Griffith RS, Black HR (1969). Comparison of blood levels following pediatric suspensions of erythromycin estolate and erythromycin ethyl succinate. Clin Med 76 16-18. 

The pharmacokinetics (elimination rate constant, half-life, AUC) of a single 400-mg dose of erythromycin ethyl succinate were not significantly altered by a single 1-g dose of sucralfate in 6 healthy subjects. It was concluded that the therapeutic effects of erythromycin are unlikely to be affected by concurrent use. ... 

Cachet, T. Lannoo, R Paesen, J. Janssen, G. Hoogmartens, J. Determination of erythromycin ethyl succinate by liquid chromatography. J.Chromatogr., 1992, 600, 99—108... 

The performance of HSCCC-ESI-MS was evaluated by analyzing erythromycins and didemnins. ° Because erythromycins (macrolide antibiotics) show weak UV absorbance and cannot be detected easily with a conventional UV detector, mass spectrometric detection is a very usefiil technique for analysis of these antibiotics. A mixture of erythromycin A (Er-A, MW 733), erythromycin estolate (Er-E, MW 789), and erythromycin ethyl succinate (Er-S, MW 789) was analyzed using HSCCC-ESI-MS with a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (4 7 4 3). TIC showed, clearly, four peaks corresponding to Er-A, Er-E, Er-S, and an unknown substance. The mass spectra of Er-E and Er-S gave [M -f H]+ at miz 862 and 789 and [M - - H - H2O] at mIz 844 and 772, respectively. In the mass spectmm of Er-A, [M -I- H - H20] was observed at miz 761 however, no [M + H] was given. The mass spectrum of the unknown peak indicated that it consists of two components with molecular weights of 843 and 772, which correspond to dehydrated Er-S and Er-E, respectively. 

Antibiotics. - Reversed-phase h.p.l.c. analyses have been reported for the following dialkylamino-sugar-containing antibiotics the anthracycline glycoside 3 -deamino-3 -[2(S)-methoxy-4-morpholinyl]doxorubicin and its possible 13-dehydro-metabolite, the macrolide antibiotics rokitamycin and josamycin as their dansylhydrazone derivatives. In addition, erythromycin ethyl succinate and its process impurities erythromycin A, the ethyl succinate esters of erythromycin B and C and A-(ethyl succinyl)-iV-demethyletythromycin A were analyzed by ion-pair reversed-phase h.p.l.c. ... 

Erythromycin Ethyl Succinate Erythromycin Propionyl Ester... 

Esters have also been used in a number of instances to mask unpleasant tastes. Examples include chloramphenicol palmitate, dindamydn palmitate and erythromycin ethyl succinate where in each case the free dmg tastes extremely unpleasant but its estetified form is tasteless. 

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