Erythrocyte metabolism

Brown FF, Campbell ID, Kuchel PW, Rabenstein DC (1977) Human erythrocyte metabolism studies by H-l spin-echo NMR. FEBS Lett 82 12-16... 

C18. Cross, R. T., Hurwitz, R. E., and Marks, P. A., An hereditary enzymatic defect in erythrocyte metabolism Glucose-6-phosphate dehydrogenase deficiency. J. Clin. Invest. 37, 1170-1184 (1958). 

Pharmacokinetics Rapidly and extensively absorbed after PO administration. Proteinbinding 50%. Widely distributed, includingtoCSFand erythrocytes. Metabolized in the liverto inactive metabolites. Primarily excreted in urine. Unknown if removed by hemodialysis. Half-life 1.5 hr. 

Brin, M. (1963). Thiamine deficiency and erythrocyte metabolism. Am. /. Clin. Nutr. 12, 107-116. 

P. J. Mulquiney P. W. Kuchel, Models of Human Erythrocyte Metabolism. In Modelling Metabolism with Mathematica CRC Press Boca Raton, FL, 2003 pp 175-196. 

Erythrocyte metabolism, pH and membrane transport studied using NMR... 

Isaacks, R.E., Harkness, D.R., Sampsell, R.N., Adler, J.L., Kim, C.Y. Goldman, P.H. (1976). Studies on avian erythrocyte metabolism-IV. Relationship between the major phos-phorylated metabolic intermediates and oxygen affinity of whole blood in adults and embryos in several Galliformes. Comp. Biochem. Physiol, 5 5A, 29—33. 

Isaacks, R.E., Kim, C., Liu, H.L., Goldman, P., Johnsoa A. Harkness, D. (1983). Studies on avian erythrocyte metabolism. XIII. Changing organic phosphate composition in age-dependent density populations of chicken erythrocytes. Poult. Sci., 62, 1639- 6. 

Erythrocyte metabolism of purines and purine nucleosides during storage and simulated physiological conditions, in "Red Cell Metabolism and Function," G. J Brewer, ed.. 

P.W. Kuchel, Current Status and Challenges in Connecting Models of Erythrocyte Metabolism to Experimental Reality , p. 325... 

Harvey JW Erythrocyte metabolism. In Clinical Biochemistry of Domestic Animals, 4th ed. Edited by Kaneko J). San Diego, Academic Press, 19B9, pp I85--234. 

Brewer, G.J., 1969, Erythrocyte metabolism and function Hexokinase inhibition by 2,3-diphosphoglycerate and interaction with ATP and Mgf+, Biochim. Biophys. Acta 192 157. 

Brewer, G. J., and Eaton, J. W., 1971, Erythrocyte metabolism Interaction with oxygen transport. Science 171 1205. 

Two commonly used drugs in human medicine, terbutaline and propranolol, have been tested concerning their effect on erythrocyte metabolism. Terbutaline is a beta-2-adrenoceptor agonist and propranolol is a beta-l-beta-2-adrenoceptor antagonist. Both drugs are taken up into the erythrocytes. 

A calorimetric study [18] was done to estimate whether propranolol and terbutaline affected human erythrocyte metabolism after short treatment with therapeutic doses of the drugs. The study had a double blind, cross-over design. Propranolol and terbutaline slow-release 7.5 mg were randomly administered twice daily for 1 week to 15 healthy non-smoking males. Placebo tablets of similar shape and colour were employed. Blood samples were taken after seven days on each drug. A "wash-out" period of at least two weeks separated each study period. Neither of the drugs was found to influence overall erythrocyte metabolism or the energy expenditure connected with the Na+ K pump. 

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