Ritonavir Ergotamine

Pregnancy (ergotamine s powerful uterine stimulant actions may cause fetal harm) hypersensitivity to ergot alkaloids peripheral vascular disease (eg, thromboangiitis obliterans, leutic arteritis, severe arteriosclerosis, thrombophlebitis, Raynaud s disease) hepatic or renal impairment severe pruritus coronary artery disease hypertension sepsis. The use of potent CYP3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is contraindicated. [Pg.969]

Deravirdine (Rescnptor) [Antiretroviral/NNRTI] Uses HIV Infxn Action Nonnucleoside RT inhibitor Dose 400 mg PO tid Caution [C, ] CDC recommends HIV-infected mothers not to breast-feed (transmission risk) w/ renal/hepatic impair Contra Use w/ drugs dependent on CYP3A for clearance (Table VI-8) Disp Tabs SE Fat redistribution, immune reconstitution synd, HA, fatigue, rash, T transaminases, N/V/D Interactions T Effects W/ fluoxetine T effects OF benzodiazepines, cisapride, clarithromycin, dapsone, ergotamine, indinavir, lovastatin, midazolam, nifedipine, quinidine, ritonavir, simvastatin, terfena-dine, triazolam, warfarin effects W/ antacids, barbiturates, carbamazepine, cimetidine, famotidine, lansoprazole, nizatidine, phenobarbital, phenytoin, ranitidine, rifabutin, rifampin effects OF didanosine EMS Use of benzodiazepines and CCBs should be avoided may cause a widespread rash located on upper body and arms OD May cause an extension of nl SEs symptomatic and supportive Deferasirox (Exjade) [Iron Chelator] Uses Chronic iron overload d/t transfusion in pts >2 y Action Oral iron chelator Dose Initial 20 mg/kg... [Pg.127]

Ritonavir has been reported to potentiate the effects of ergotamine. [Pg.1233]

Ritonavir is a very potent inhibitor of CYP3A4, which is responsible for the metabolism of ergotamine, and this interaction obviously led to toxic plasma concentrations of the alkaloid. [Pg.1234]

Liaudet L, Buclin T, Jaccard C, Eckert P. Drug points severe ergotism associated with interaction between ritonavir and ergotamine. BMJ 1999 318(7186) 771. [Pg.1235]

Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W. Cerebral ergotism under treatment with ergotamine and ritonavir. Neurology 2001 57(4) 743. ... [Pg.1235]

Montero A, Giovannoni AG, Tvrde PL. Leg ischemia in a patient receiving ritonavir and ergotamine. Ann Intern Med I999 I30(4 Pt I) 329-30. [Pg.2162]

Clinically important, potentially hazardous interactions with amiodarone, amitriptyline, amoxapine, benzodiazepines, bepridil, clomipramine, clonazepam, clorazepate, delavirdine, desipramine, diazepam, dihydroergotamine, doxepin, ergotamine, fentanyl, flurazepam, imipramine, ixabepilone, lidocaine, lorazepam, methysergide, midazolam, nortriptyline, oxazepam, phenytoin, protriptyline, quazepam, quinidine, rifampin, ritonavir, sildenafil, St John s wort, temazepam, tricyclic antidepressants, trimipramine, vitamin E... [Pg.36]

Clinically important, potentially hazardous interactions with amiodarone, astemizole, bepridil, carbamazepine, chloroquine, cisapride, clarithromycin, dihydroergotamine, disopyramide, ergotamine, grapefruit juice, halofantrine, haloperidol, itraconazole, ketoconazole, methadone, moxifloxacin, phenobarbital, phenytoin, pimozide, procainamide, quinidine, rifampicin, ritonavir, sotalol, St John s wort, telithromycin, terfenadine, voriconazole... [Pg.410]

Vila A et al Clinical ergotism induced hy ritonavir. Scand J Infect Dis 2001 33(10) 788-789. [PMID 11728055] (Case report of ergotism due to concomitant use of ergotamine with ritonavir, a cytochrome P-450 inhihitor.)... [Pg.190]

See (c) ritonavir below for details regarding a fatality involving indinavir, ritonavir and ergotamine. [Pg.600]

A fatality has been reported in a 49-year-old man taking ritonavir 200 mg twice daily and indinavir 800 mg twice daily in addition to stavu-dine and lamivudine. After taking three tablets of Cafergot (ergotamine tartrate 1 mg and caffeine 100 mg) his headache worsened, he developed progressive lower extremity weakness, severe peripheral vasoconstriction, labile hypertension and livedo reticularis (skin discolouration due to underlying capillary changes). He lapsed into coma and on day 5 was declared brain dead . ... [Pg.601]

Caballero-Granado FJ, Viciana P, Cordero E, Gomez-Vera MJ, delNozal M, L6pez Cc tes LF. Ergotism related to concurrent administtation of ergotamine tartrate and ritonavir in an AIDS patient. Antimicrob Agents Chemother ( 991), 41,1207. [Pg.601]

Pardo Rey C, Yebra M, Borrallo M, Vega A, Ramos A, Montero MC. Irreversible coma, ergotamine and ritonavir. Clin InfectDis (2003) 37, e72-3. [Pg.601]

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