Ergosterol biosynthesis inhibitors effectiveness

U.S. 6514490 (2003) Odds et al. (Janssen Pharmaceutica) Ergosterol biosynthesis inhibitor 1 O -undecen-3 -oyl-aminopropyl trimethylammonium methylsulfate Effective antifungal and antidandruff composition... 

F. (2007) Effect of two ergosterol biosynthesis inhibitors on lycopene production by Blakeslea trispora. 

Terbinafme (Fig. 5.171), a member ofthe allylamine class ofantimycotics, is an inhibitor of the enzyme squalene epoxidase in fungal ergosterol biosynthesis. Terbinafme is orally active, is fungicidal and is effective against a broad range of dermatophytes and yeasts. It can also be used topically as a cream. 

However, there are other changes. There is an increase in sterol (chiefly ergosterol) and a shift in the relative proportions of carotenoids (8). These effects are prevented by the protein synthesis inhibitor cycloheximide (9). Since carotenoids and sterols share a common biosynthesis to farnesyl pyrc hosphate, the hormones must act by derepressing the synthesis of enzjnnes early in this pathway. Preliminary experiments have shown that mevalonate kinase activities are unaffected by trisporic acid, indicating that this is Unlikely to be the limiting enzjnae a more likely candidate is 3-hydroxy-3 ethylglutaryl CoA reductase. 

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