Ergosterol biosynthesis discussion

In the discussion of the mode of action of ergosterol biosynthesis inhibitors, the question of the function of sterols in mem-... 

Sterol biosynthesis inhibiting insecticides. The earliest examples of sterol biosynthesis inhibitors were triadimefon, imazalil, and triarimol. These compounds act by blocking the C14 alpha demethylation step in ergosterol biosynthesis [54], Further work in this area has resulted in numerous fungicides, a number of them containing aromatic fluorine, perfluoroalkyl ethers, and the trifluoromethylphenyl group (Fig. 11). In this section, we will discuss the trifluoromethylphenyl sterol biosynthesis inhibitors, such as triflumizole and fluotrimazole. 

Exploration of the area of imidazole-l-carboxamides has led to the discovery of prochloraz, a broad-spectrum fungicide for use on a variety of crops. Prochloraz and its analogues are inhibitors of ergosterol biosynthesis and structure-activity relationships in the area are discussed. In particular, the usefulness of an in vitro assay for sterol biosynthesis as a guide to the chemical effort is considered. Finally, the biological activity of prochloraz is briefly described. 

As in the previous Report/ the biosynthesis of steroids and triterpenoids is divided into three sections. This section considers the biosynthesis of cholesterol and related steroids, such as ergosterol. Further metabolism of cholesterol is reviewed in Section 8, whereas non-steroidal triterpenoids are considered in Section 9. The biosynthesis of steroids in lower organisms and arthropod steroid metabolism are discussed in Section 11. 

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