Ergonovine

Synonyms 9,10-didehydro-A-(o -(hydroxy-methyl)ethyl)-6-methylergoline-8-/6-car- 

Ergonovine is a water-soluble lysergic acid derivative that occurs in ergot. It is used as an oxytocic agent. Its maleate derivative is used in the treatment of postpartum hemorrhage. 

This compound is a homologue of ergonovine. It is used in the treatment of postpartum hemorrhage. 

Crystalline solid, obtained as fine needles or solvated crystals from benzene or ethyl acetate melts at 162°C (323.6°F) solution alkaline, piT 6.8 soluble in water, alcohol, acetone, and ethyl acetate. 

The toxicity of ergonovine is low to moderate. The toxic symptoms include excitability, respiratory depression, cyanosis, and convulsions. The intravenous LD50 value in mice is 144 mg/kg. 

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R =101) and ergonovine (100, R = NHCH(CH3)CH20H) are produced. Ergotamine is obtained from cmde extract by formation of an aluminum complex which can then be defatted. 

Ergonovine (100, R = NHCH(CH3)CH2 0H) was found to yield lysergic acid (100, R = OH) and (+)-2-aminopropanol on alkaline hydrolysis during the early analysis of its stmcture (66) and these two components can be recombined to regenerate the alkaloid. Salts of ergonovine with, for example, malic acid are apparently the dmgs of choice in the control and treatment of postpartum hemorrhage. 

Ergonovine and methylergonovine both increase the strength, duration, and frequency of uterine contractions and decrease the incidence of uterine bleeding. They are given after the delivery of the placenta and are used to prevent postpartum and postabortal hemorrhage caused by uterine atony (marked relaxation of the uterine muscle). 

Ergonovine is contraindicated in those with known hypersensitivity to the drug, hypertension, and before the delivery of the placenta Ergonovine is used cautiously in patients with heart disease obliterative vascular disease, renal or hepatic disease and during lactation. 

Ergonovine and metiiylergonovine may be given orally during die postpartum period to reduce die possibility of postpartum hemorrhage and to prevent relaxation of die uterus. When die patient is to receive eitiier of tiiese drains after delivery, it is important to take die blood pressure, pulse, and respiratory rate before administration. 

When ergonovine or methylergonovine is administered in the delivery room, the nurse briefly explains die purpose of die injection to the patient. If either of diese dragp is given after delivery of die infant, die nurse explains the purpose of die drug (eg, to improve die tone of the uterus and to help die uterus to return to its [near] normal size). 

Although rare, ergotism or ergot poisoning can occur with the administration of excessive amounts of ergonovine or methylergonovine... 

In some patients who are calcium deficient, the uterus may not respond to ergonovine. The nurse immediately reports a ladk of response to ergonovine. Administration of calcium by tV injection usually restores response to the drug. 

Ermetrin (Takeda) USA Ergonovine Maleate (Bioline City Chem. Goldline Wyeth) wfm... 

Some of these natural products—and drugs made from them—are known collectively as the ergot alkaloids, and have found use in medicine. Ergonovine, for example, is a selective stimulant for contraction of uterine muscle and is used in conjunction with labor and delivery. A mixture of hydrogenated ergot alkaloids—reduced at the 9,10-position—has found... 

Erectile dysfunction, therapeutics for, 5 182-183t Ergocalciferol, 25 791 Ergonovine, 2 93-94 Ergosterol, 25 791 Ergotamine, 2 93-94 Ergotism, alkaloid role in, 2 75 Ergun equation, 11 332-333, 767 Erionite, 3 289... 

Ergot alkaloids (ergotamine, ergonovine) also exhibit certain nonselective a-adrenoblocking activity however, they primarily exhibit spasmogenic action on smooth muscle, causing a constriction of blood vessels. 

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