Alkaloids ergonovine

Ergot alkaloids Ergonovine causes prolonged uterine contraction. Used in postpartum bleed-... 

Ergonovine (100, R = NHCH(CH3)CH2 0H) was found to yield lysergic acid (100, R = OH) and (+)-2-aminopropanol on alkaline hydrolysis during the early analysis of its stmcture (66) and these two components can be recombined to regenerate the alkaloid. Salts of ergonovine with, for example, malic acid are apparently the dmgs of choice in the control and treatment of postpartum hemorrhage. 

Some of these natural products—and drugs made from them—are known collectively as the ergot alkaloids, and have found use in medicine. Ergonovine, for example, is a selective stimulant for contraction of uterine muscle and is used in conjunction with labor and delivery. A mixture of hydrogenated ergot alkaloids—reduced at the 9,10-position—has found... 

Erectile dysfunction, therapeutics for, 5 182-183t Ergocalciferol, 25 791 Ergonovine, 2 93-94 Ergosterol, 25 791 Ergotamine, 2 93-94 Ergotism, alkaloid role in, 2 75 Ergun equation, 11 332-333, 767 Erionite, 3 289... 

Ergot alkaloids (ergotamine, ergonovine) also exhibit certain nonselective a-adrenoblocking activity however, they primarily exhibit spasmogenic action on smooth muscle, causing a constriction of blood vessels. 

Ergot alkaloids were the first adrenoblockers to be studied. Despite the fact that the majority of ergot alkaloids exhibit a-adrenoblocking activity, their pharmacology is often different. In terms of chemistry, ergotamine and ergonovine are derivatives of lysergic acid. 

In 1935 ergometrine was discovered in four different laboratories almost simultaneously and described under four different names (74, 75, 76, 77). Although the names ergometrine and ergobasine have remained in use in Europe, ergonovine was adopted in the USA as the official nomenclature for the specific uterotonic ergot alkaloid. 

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