Eradication of Helicobacter pylori C

This organism plays an important role in the pathogenesis of chronic gastritis and peptic ulcer disease. The combination of antibacterial drugs and omeprazole has proved effective. If amoxicillin (p. 272) or clarithromycin (p.278) cannot be tolerated, metronidazole (p. 276) may serve as a substitute. Colloidal bismuth compounds are also effective however, as they entail the problem of heavy-metal exposure, this treatment can no longer be recommended. 

Sucralfate (A) contains numerous aluminum hydroxide residues. However, it is not an antacid because it fails to lower the overall acidity of gastric juice. After oral intake, sucralfate molecules undergo cross-linking in gastric juice, forming a paste that adheres to mucosal defects and exposed deeper layers. 

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Laxatives promote and facilitate bowel evacuation by acting locally to stimulate intestinal peristalsis, to soften bowel contents, or both. 

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