Epirubicin

MRP1 (ABCC1) Glucuronides and sulfate conjugates of steroid hormones and bile salts, colchicine, doxorubicin, daunorubicin, epirubicin, folate, irinotecan, methotrexate, pacitaxel, vinblastine, vincristine, and others... 

C5H12O2 77-76-9) see Atorvastatin calcium Dibekacin Docetaxel Doxifluridine Epirubicin Indinavir sulfate lotrolan Misoprostol Oseltamivir acetonitrile... 

C4F Oj 407-25-0) see Dofetilide Dolasetron mesilate Epirubicin Imiquimod Vinorelbine... 

Epirubicin, a successor to adriamycin, was studied in ovalbumin microspheres (115). The microspheres, prepared by a heat denatu-ration process, were 20 ym in diameter and contained 12.5% drug. 

Restricted access phases are another approach to exploiting the differences in characteristics of analytes. Large analytes are excluded from an internal surface on which an adsorptive stationary phase is present. A herbicide analysis for Metsulfuron methyl, Bentazone, Bromoxynil, methylchlorophenoxy acid, and Mecoprop in the presence of humic acid was performed on restricted access reversed phase media.52 The cytostatic compound epirubicin and its metabolites were separated from plasma using a Pinkerton GFF II column.53 Gradient separations of polymers on reversed phase and on normal phase represent an alternative to gel permeation chromatography. Polyesters of noncrystalline materials were separated on a variety of such phases.54... 

Epirubicin inhibits both DNA and RNA polymerases and thus inhibits nucleic acid synthesis and topoisomerase II enzymes. Epirubicin pharmacokinetics are best described by a three-compartment model, with an a half-life of 4 to 5 minutes, a... 

Cytotoxic drugs that have been used alone and in combination as adjuvant therapy in breast cancer include doxorubicin, epirubicin, cyclophosphamide, methotrexate, fluorouracil,... 

Epirubicin 60 mg/m2 IV, days 1 and 8 Fluorouracil 600 mg/m2 IV, days 1 and 8 Repeat cycles every 21 days for 6 cycles (requires prophylactic antibiotics or growth factor support) ... 

Docetaxel + capecitabine Docetaxel 75 mg/m2 IV over 1 hour, day 1 Capecitabine 2000-2500 mg/m2 per day orally divided twice daily for 14 days Repeat cycles every 21 days Epirubicin + docetaxel" Epirubicin 70-90 mg/m2 IV bolus Followed by Docetaxel 70-90 mg/m2 IV over 1 hour Repeat cycles every 21 daysv Doxorubicin + docetaxel" Doxorubicin 50 mg/m2 IV bolus, day 1 Followed by Docetaxel 75 mg/m2 IV over 1 hour, day 1 Repeat cycles every 21 days"... 

Paclitaxel also may be given concurrently with doxorubicin or epirubicin as a combination regimen. Pharmacokinetic interactions make these regimens more difficult to give. 

Anthracyclines Doxorubicin, epirubicin Myelosuppression, cardiomyopathy Alopecia, nausea, vomiting, stomatitis, ulceration necrosis with extravasation, red-colored urine, radiation-recall effect... 

Epirubicin-monitor cumulative dose for cardiac toxicity (not to exceed 1000 mg/M2) vesicant—avoid extravasation... 

Epirubicin -anthracycline antitumor antibiotic—DNA intercalating agent -bone marrow suppression -nausea and vomiting -mucocutaneous effects (mucositis, stomatitis) -cardiotoxicity (1000 mg/M2) -vesicant if extravasated -rash and hyperpigmentation -alopecia... 

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