Epirubicin Verapamil

Acyclovir Erythromycin Ivermectin Itraconazole Rifampin Actinomycin D Daunorubicin Doxorubicin Docetaxel Epirubicin Etoposide Imatinib Irinotecan Paclitaxel Vinblastine Vincristine Amprenavir Indinavir Nelfinavir Ritonavir Saquinavir Cyclosporine A Tacrolimus Digoxin Quinidine Verapamil Diltiazem Aldosterone Cortisol Corticosterone Dexamethasone Hydrocortisone Cyclosporine Metkephamid Enkephalin... 

CALCIUM CHANNEL BLOCKERS EPIRUBICIN Cases of T bone marrow suppression when verapamil is added to epirubicin Uncertain at present Monitor FBC closely... 

Biochemical abnormahties have been reported in trials of intravesical epirubicin. In one trial, liver function tests were impaired in seven of 40 patients who received epirubicin and in 10 of 35 patients who received epirubicin and verapamil concomitantly (101). In another study, liver function tests were impaired in one of 69 patients who received combination prophylaxis with epirubicin 50 mg and BCG 150 mg after transurethral resection (102). 

Lukkarinen O, Paul C, Hellstrom P, Kontturi M, Nurmi M, Puntala P, Ottelin J, Tammela T, Tidefeldt U. Intravesical epirubicin tvith and without verapamil for the prophylaxis of superficial bladder tumours. Scand J Urol Nephrol 1991 25(l) 25-8. 

Verapamil can increase the efficacy of doxorubicin in tissue culture systems and increase doxorubicin levels in patients. D-vera-pamil can alter the pharmacokinetics of epirubicin and possibly increase its bone marrow depressant effects. 

Scheithauer W, Schenk T, Czejka M. Pharmacddnetic interaction between epirubicin and the multidrug resistance reverting agent D-verapamil. BrJ Cancer (1993) 68, 8-9. 

Mross K, Hamm K, Hossfeld DK. Effects of verapamil on tiie pharmacokinetics and metabolism of epirubicin. Cancer Chemo er Pharmacol (1993) 31,369-75. 

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