Epibatidine cholinergic

Pauly JR, Ullman EA, CoUins AC (1990b) Strain differences in adrenalectomy-induced alterations in nicotine sensitivity in the mouse, Pharmacol Biochem Behav 35 171-179 Pauly JR, Marks MJ, Gross SD, Collins AC (1991) An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment, J Pharmacol Exp Ther 258 1127-1136 Perry DC, KeUar KJ (1995) [ H]epibatidine labels nicotinic receptors in rat brain an autoradiographic study. J Pharmacol Exp Ther 275 1030-1034 Perry WLM, Talesnik J (1953) The role of acetylchoUne in synaptic transmission at parasympathetic ganglia. J Physiol 119 455 69... 

Davila-Garcia, M.I., Musachio, J.L., Perry, D.C., Xiao, Y.X., Horti, A., London, E.D., Dannals, R.F., Kellar, K.J., 1997. [ l]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors. J. Pharmacol. Exp. Ther. 282, 445-451. 

The Baltz-Schiemann reaction is the most often used method for the synthesis of 3-fluoropyridines. This method utilizes readily accessible 3-nitropyridines as the precursors, since they can be readily reduced into amines and then used in the Baltz-Schiemann reaction. In this section, selected examples applied for the synthesis of practically important compounds are given. For example, the Baltz-Schiemann reaction was used for the synthesis of fluoro-substituted epibatidine analogue 79 (epibatidine is a high-affinity nonselective ligand for nicotinic cholinergic receptor (nAChRs)) (Scheme 6.27). 

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