Selegiline Ephedrine

TABLE 4 Effects of pH on the Chiral Resolution of Ephedrine, Methamphetamine, and Selegiline... 

FlGURE 12 The effects of anions on the chiral resolution of ephedrine (A), meth-amphetamine ( ), and selegiline (O) on ChiraDex columns. (From Ref. 112.)... 

J Sevcik, Z Stransky, BA Ingelse, K Lemr. Capillary electrophoretic enantiosepara-tion of selegiline, methamphetamine and ephedrine using a neutral beta-cyclodex-trin epichlorhydrin polymer. J Pharm Biomed Anal 14 1098-1094, 1996. 

An isolated report describes a hypertensive crisis, which was attributed to an interaction between selegiline, ephedrine, and maprotiline. 

It is thought that this reaction occurred as a result of excess sympathomimetic amines ephedrine is an indirectly-acting sympathomimetic that causes increased release of noradrenaline selegiline has some MAO-A in-... 

Stock solutions. The following are available as 1 mg/mL methanolic stocks (Cerilliant, Round Rock, TX) ephedrine, methylephedrine, pseudoephedrine, phenylpropanolamine, amphetamine, phentermine, methamphetamine, 3,4-methyl-enedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethylamphetamine (MDEA), selegiline, dj-ephedrine, dj-phenylpropanolamine, dj-amphetamine, dj-methamphetamine, d -MDA, d -MDMA, dj-MDEA. Norpseudoephedrine, dg-selegiline, and dj-pseudoephedrine are available as 0.1 mg/mL methanolic stocks (Cerilliant, Round Rock, TX). Phendimetrazine (Alltech Associates, Lancaster, PA) and phenmetrazine (USP, Rockville, MD) are available as powders to create the stock standards, dissolve the powders in methanol to a concentration of 1 mg/ mL. 

Mixed amphetamines panel substock standard A. Add 5 mL of deionized water to a 10 mL volumetric flask. Add 10 J.L of concentrated hydrochloric acid and mix well. Quantitatively add the stock standards as follows 100 pL each ephedrine, methylephedrine, pseudoephedrine, phenylpropanolamine, amphetamine, phentermine, methamphetamine, MDA, MDMA, phendimetrazine, phenmetrazine 200 i,L MDEA 50 pL selegiline 1,000 pL norpseudoephedrine. Dilute to volume with deionized water cap and mix by inversion. Store between 2 and 8°C in an amber bottle with Teflon -lined cap. Final concentration for all compounds is 10 pg/mL except MDEA (20 pg/mL) and selegiline (5 pg/mL). 

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